Święczkowski Michał, Lip Gregory Y H, Kurasz Anna, Dąbrowski Emil J, Tomaszuk-Kazberuk Anna, Kamiński Jacek W, Strużewska Joanna, Dobrzycki Sławomir, Kuźma Łukasz
Department of Invasive Cardiology, Medical University of Białystok, Skłodowskiej-Curie 24a, 15-276 Bialystok, Poland.
Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, UK.
Eur J Prev Cardiol. 2025 Mar 18;32(4):276-287. doi: 10.1093/eurjpc/zwae301.
Short-term effects of Polish smog, particularly benzo(alpha)pyrene [B(a)P], are unclear. We aimed to examine the association between short-term exposure to air pollution and ischaemic stroke (IS) incidence.
We conducted a retrospective population-based cohort study including an EP-PARTICLES cohort of 8 million inhabitants in the years 2011-20 (80 million person-years of observation). Individual clinical data on emergency hospitalizations due to IS (ICD-10: I63.X) was analysed. We used quasi-Poisson models to examine municipality-specific associations between air pollutants and IS, considering various covariates. We recorded 146 262 cases of IS with a dominance of females (51.8%) and people over 65 years old (77.6%). In the overall population, exposure to PM2.5, NO2, B(a)P, and SO2 increased the risk of IS onset on the day of exposure by 2.4, 1, 0.8, and 0.6%, respectively. Age and sex were modifying variables for PM2.5, NO2, and B(a)P exposure with more pronounced effects in non-elderly individuals and women (all Pinteraction < 0.001). Residents of regions with high tobacco and alcohol consumption were more sensitive to the effects of PM2.5 and SO2. The slopes of response-effect curves were non-linear and steeper at lower concentrations.
Exposure to air pollution may be associated with higher IS incidence, particularly posing a higher risk to non-elderly women. Harmful lifestyle habits might exacerbate its impact. Exposure to even low levels of air pollutants had negative effects.
The study was registered at ClinicalTrials.gov (NCT05198492).
波兰雾霾的短期影响，尤其是苯并（α）芘[B（a）P]的影响尚不清楚。我们旨在研究短期接触空气污染与缺血性中风（IS）发病率之间的关联。
我们进行了一项基于人群的回顾性队列研究，纳入了2011年至2020年期间800万居民的EP - PARTICLES队列（8000万人年的观察期）。分析了因IS（国际疾病分类第十版：I63.X）导致的急诊住院的个体临床数据。我们使用准泊松模型，考虑各种协变量，研究空气污染物与IS之间的特定城市关联。我们记录了146262例IS病例，其中女性占主导（51.8%），65岁以上人群占77.6%。在总体人群中，接触PM2.5、NO2、B（a）P和SO2分别使暴露当天IS发病风险增加2.4%、1%、0.8%和0.6%。年龄和性别是PM2.5、NO2和B（a）P暴露的修正变量，在非老年个体和女性中影响更显著（所有P交互作用<0.001）。烟草和酒精消费量高的地区居民对PM2.5和SO2的影响更敏感。反应 - 效应曲线的斜率是非线性的，在较低浓度时更陡峭。
接触空气污染可能与较高的IS发病率相关，尤其对非老年女性构成更高风险。有害的生活习惯可能会加剧其影响。即使接触低水平的空气污染物也有负面影响。
该研究已在ClinicalTrials.gov注册（NCT05198492）。
