Biswas Ujjwal Kumar, Bose Anindya, Parmanik Ankita
School of Pharmaceutical Science (SPS), Siksha O Anusandhan (SOA) University, K.8, Kalinga Nagar, Ghatkia, Bhubaneswar- 751003, Odisha, India.
Pharm Nanotechnol. 2024 Sep 19. doi: 10.2174/0122117385333634240911075833.
Solid lipid nanoparticles (SLNs) are one of the extensively utilized nanocarriers in the pharmaceutical field due to their biocompatibility and biodegradability. These features of the carrier system have fuelled its use as the drug delivery system since the last three decades. This review presents different SLN preparation techniques, such as high shear homogenization, hot homogenization, cold homogenization, microemulsion-based technique, etc. The physicochemical nature of SLNs, comprising drug loading, drug release, particle size, zeta potential, stability, cytotoxicity, and cellular uptake, has been concisely discussed. The article also explains why SLNs are preferred to develop drug delivery systems in several pharmaceutical preparations. The key ingredients like lipid, surfactant/ stabilizer accompanied by co-surfactant, cryoprotectant, or charge modifiers used to fabricate SLNs are also briefly conferred. Here is an elaborate discussion of drugs that are used through various routes by the SLN carrier system and their outcome for utilization of this system. Regulatory aspects, patent aspects, and future prospects of SLN are also discussed here.
固体脂质纳米粒（SLNs）因其生物相容性和生物可降解性，是制药领域广泛应用的纳米载体之一。自过去三十年来，载体系统的这些特性推动了其作为药物递送系统的应用。本综述介绍了不同的SLN制备技术，如高剪切均质化、热均质化、冷均质化、微乳液法等。简要讨论了SLNs的物理化学性质，包括载药量、药物释放、粒径、zeta电位、稳定性、细胞毒性和细胞摄取。文章还解释了为什么在几种药物制剂中开发药物递送系统时更倾向于使用SLNs。还简要介绍了用于制备SLNs的关键成分，如脂质、表面活性剂/稳定剂以及辅助表面活性剂、冷冻保护剂或电荷调节剂。这里详细讨论了通过SLN载体系统以各种途径使用的药物及其使用该系统的效果。还讨论了SLN的监管方面、专利方面和未来前景。
