Ollinger H, Gruber J, Singer F
EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. 1985 Jun;16(2):104-7.
The following drugs, mostly postulated acting at a supraspinal or spinal level as diazepam, chlormezanone and orphenadrine citrate were proved for their effectiveness in lessening tension of muscles. This was assessed by electromyography recording different neurophysiological phenomenons as mono- and polysynaptic reflex responses (H-reflex and unloading reflex as a result of a suddenly muscle relaxation (= post-reflex inhibition phase/silent period) and tiredness reaction. This investigations were performed on at least 65 patients. The outcomes are: statistical significant increase of the silent period of the unloading reflex under the treatment with diazepam and orphenadrine citrate. Diazepam also extended the time between the initial electric stimulus and H-reflex phenomenon. Evaluating these results it might be obvious that diazepam is acting on supraspinal level and the spinal too, orphenadrine citrate only on the supraspinal one. Chlormezanone showed no effect according to that protocol on all mentioned neurophysiological parameters.
以下药物，大多被假定作用于脊髓上或脊髓水平，如地西泮、氯美扎酮和枸橼酸奥芬那君，已被证明在减轻肌肉紧张方面有效。这是通过肌电图记录不同的神经生理现象来评估的，如单突触和多突触反射反应（H反射以及由于突然的肌肉松弛导致的卸载反射（=反射后抑制期/静息期）和疲劳反应）。这些研究至少在65名患者身上进行。结果如下：在地西泮和枸橼酸奥芬那君治疗下，卸载反射的静息期有统计学显著增加。地西泮还延长了初始电刺激与H反射现象之间的时间。评估这些结果可能会发现，地西泮作用于脊髓上水平，也作用于脊髓，而枸橼酸奥芬那君仅作用于脊髓上水平。根据该方案，氯美扎酮对所有提及的神经生理参数均无影响。
