Iriki A, Ikezono E, Toda K, Tanaka H
Bull Tokyo Med Dent Univ. 1980 Mar;27(1):1-7.
Effec of an i.p. injection of diazepam on the jaw opening reflex evoked by electrical stimuli applied to the tooth pulp innervated by mainly high threshold afferents and the lower lip innervated by low threshold afferents was investigated using Wistar albino rats. Small doses of diazepam, less than 2.5 mg/kg, suppressed to the same degree the jaw opening reflexes evoked by stimulation of tooth pulp or lower lip. However, when larger doses thab 5.0 mg/kg were administered, the suppression of tooth pulp-evoked jaw opening reflex was greater than that of lower lip-evoked one. In this case, the period of suppression of tooth pulp-evoked jaw opening reflex was longer than that of lower lip-evoked one. It is concluded that (1) the pain relieving effect of diazepam appears only when larger doses tha 5.0 mg/kg are administered and that (2) the pain-relieving effect lasts longer than muscle-relaxative effect of diazepam.
使用Wistar白化大鼠，研究了腹腔注射地西泮对主要由高阈值传入神经支配的牙髓和由低阈值传入神经支配的下唇施加电刺激所诱发的下颌张开反射的影响。小于2.5mg/kg的小剂量地西泮对刺激牙髓或下唇所诱发的下颌张开反射具有相同程度的抑制作用。然而，当给予大于5.0mg/kg的较大剂量时，牙髓诱发的下颌张开反射的抑制作用大于下唇诱发的反射。在这种情况下，牙髓诱发的下颌张开反射的抑制期比下唇诱发的反射更长。得出的结论是：（1）仅当给予大于5.0mg/kg的较大剂量时，地西泮才会出现止痛效果；（2）止痛效果比地西泮的肌肉松弛效果持续时间更长。
