Sanaka Harsha, Haroun Elio, Arockiam Aro Daniela, Dong Tiffany, Klein Allan, Wang Tom Kai Ming
Biomedical Science Undergraduate Program, The Ohio State University College of Medicine, Columbus, OH, 43210, USA.
Pericardial Diseases Center, Section of Cardiovascular Imaging, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Curr Cardiol Rep. 2024 Dec;26(12):1359-1375. doi: 10.1007/s11886-024-02133-3. Epub 2024 Sep 20.
To outline recent advances in imaging and treatment for recurrent pericarditis (RP).
Greater understanding of NLRP3 inflammasome activation in the pathogenesis of RP has led to the development of several anti-interleukin (IL-1) agents, and technological advancements have increased the utility of multimodality imaging in RP. Multimodality imaging plays a crucial role in the assessment of RP, with echocardiography serving as the initial imaging modality; cardiac magnetic resonance (CMR) as a pivotal test for diagnosis, grading severity, and surveillance; and cardiac computed tomography (CT) providing complimentary information and assisting operative assessment. Anti-IL-1 agents are now well-established as second line therapy for RP, with recent clinical trials demonstrating their efficacy.
概述复发性心包炎(RP)在成像和治疗方面的最新进展。
对RP发病机制中NLRP3炎性小体激活的更深入了解促使了几种抗白细胞介素(IL-1)药物的研发,技术进步提高了多模态成像在RP中的应用价值。多模态成像在RP评估中起着关键作用,超声心动图作为初始成像方式;心脏磁共振成像(CMR)是诊断、严重程度分级和监测的关键检查;心脏计算机断层扫描(CT)提供补充信息并辅助手术评估。抗IL-1药物现已成为RP的二线标准治疗药物,近期临床试验证明了其疗效。