Araki H, Kawashima K, Uchiyama Y, Aihara H
Eur J Pharmacol. 1985 Jul 31;113(3):313-8. doi: 10.1016/0014-2999(85)90078-0.
The suppressive effect of systemic injection of desipramine and imipramine on the duration of immobility in rats forced to swim was inhibited by 6-hydroxydopamine given into the medial amygdaloid nucleus as a pretreatment. Pretreatment with 5,7-dihydroxytryptamine given into the medial amygdaloid nucleus had no effect on the immobility-reducing effect of tricyclic antidepressants. The concentrations of catecholamines and serotonin in 6-hydroxydopamine- and 5,7-dihydroxytryptamine-pretreated rats, respectively, were significantly lower than those in the saline-injected rats. These results suggest that the suppressive effect of systemic injection of desipramine and imipramine on the duration of the immobility of rats forced to swim was mediated by the catecholaminergic but not the serotonergic mechanisms in the medial amygdaloid nucleus.
作为预处理，向杏仁核内侧注射6-羟基多巴胺可抑制系统注射地昔帕明和丙咪嗪对强迫游泳大鼠不动时间的抑制作用。向杏仁核内侧注射5,7-二羟基色胺进行预处理，对三环类抗抑郁药的减少不动时间的作用没有影响。分别接受6-羟基多巴胺和5,7-二羟基色胺预处理的大鼠体内儿茶酚胺和5-羟色胺的浓度显著低于注射生理盐水的大鼠。这些结果表明，系统注射地昔帕明和丙咪嗪对强迫游泳大鼠不动时间的抑制作用是由杏仁核内侧的儿茶酚胺能机制而非5-羟色胺能机制介导的。
