Sun Haitao, Sun Zhenrong, Wang Xue-Bin
State Key Laboratory of Precision Spectroscopy, School of Physics and Electronic Science, East China Normal University, Shanghai, 200241, China.
Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan, Shanxi, 030006, China.
Chemistry. 2024 Nov 26;30(66):e202402766. doi: 10.1002/chem.202402766. Epub 2024 Oct 31.
Noncovalent interactions (NCIs) are crucial for the formation and stability of host-guest complexes, which have wide-ranging implications across various fields, including biology, chemistry, materials science, pharmaceuticals, and environmental science. However, since NCIs are relatively weak and sensitive to bulk perturbation, direct and accurate measurement of their absolute strength has always been a significant challenge. This concept article aims to demonstrate the gas-phase electrospray ionization (ESI)-negative ion photoelectron spectroscopy (NIPES) as a direct and precise technique to measure the absolute interaction strength, probe nature of NCIs, and reveal the electronic structural information for host-guest complexes. Our recent studies in investigating various host-guest complexes that involve various types of NCIs such as anion-π, (di)hydrogen bonding, charge-separated ionic interactions, are overviewed. Finally, a summary and outlook are provided for this field.
非共价相互作用（NCIs）对于主客体复合物的形成和稳定性至关重要，这在包括生物学、化学、材料科学、制药和环境科学在内的各个领域都具有广泛的影响。然而，由于非共价相互作用相对较弱且对整体扰动敏感，直接准确地测量其绝对强度一直是一项重大挑战。这篇概念文章旨在证明气相电喷雾电离（ESI）负离子光电子能谱（NIPES）是一种直接且精确的技术，可用于测量绝对相互作用强度、探究非共价相互作用的本质，并揭示主客体复合物的电子结构信息。本文概述了我们最近在研究涉及各种类型非共价相互作用（如阴离子-π、（双）氢键、电荷分离离子相互作用）的各种主客体复合物方面的研究。最后，对该领域进行了总结和展望。
