Dzgoeva F Kh, Ekusheva E V, Demidova V V
Endocrinology Research Centre.
Academy of Postgraduate Education of the Federal Research and Clinical Centre for Specialized Medical Care and Medical Technologies; Belgorod State National Research University.
Probl Endokrinol (Mosk). 2024 Sep 16;70(4):75-83. doi: 10.14341/probl13389.
Obesity is a chronic disease, heterogeneous in etiology and clinical manifestations, progressing with a natural course, characterized by excessive deposition of fat mass in the body. This pathological condition has taken on the scale of a global epidemic in recent years, which continues to progress steadily, currently affecting more than 2 billion people worldwide. Due to its heterogeneity, obesity has a negative impact on the work of almost all organs and systems of the body, contributing to the emergence of new concomitant diseases and pathological conditions that significantly worsen the quality of life of these patients. Thus, a close relationship between type 2 diabetes mellitus and cognitive impairment has long been known, as well as with a number of other somatic diseases: coronary heart disease, atherosclerosis, non-alcoholic fatty liver disease, dyslipidemia, malignant neoplasms and other associated pathological conditions against the background of overweight and obesity.Currently, the problem of the relationship of cognitive impairment in patients with overweight or changes in the glycemic profile is very relevant, due to the high prevalence and insufficient study of this issue.
肥胖是一种慢性疾病，病因和临床表现具有异质性，呈自然病程进展，其特征是体内脂肪大量过度沉积。近年来，这种病理状况已发展成为全球性的流行病，且仍在稳步蔓延，目前全球有超过20亿人受其影响。由于其异质性，肥胖对身体几乎所有器官和系统的功能都有负面影响，会引发新的伴随疾病和病理状况，严重恶化这些患者的生活质量。因此，2型糖尿病与认知障碍之间的密切关系早已为人所知，肥胖还与许多其他躯体疾病相关，如冠心病、动脉粥样硬化、非酒精性脂肪性肝病、血脂异常、恶性肿瘤以及超重和肥胖背景下的其他相关病理状况。目前，超重患者认知障碍或血糖谱变化之间关系的问题非常关键，因为该问题的患病率很高但研究不足。
