School of Mechanical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran.
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Italy.
Clin Neurol Neurosurg. 2024 Nov;246:108542. doi: 10.1016/j.clineuro.2024.108542. Epub 2024 Sep 11.
Based on the literature, tensor-based morphometry (TBM) parameters were related to neurocognitive functions such as memory, learning, language ability, and executive functions. The present study aims to evaluate the associations between TBM indices with executive functions, memory, language, and visuospatial abilities and the value of TBM in the clinical diagnosis of Alzheimer's disease (AD) among individuals with Alzheimer's disease continuum and mild cognitive impairment (MCI) from Alzheimer's Disease Neuroimaging Initiative (ADNI).
The authors used ADNI-memory (ADNI-MEM), ADNI-executive functions (ADNI-EF), ADNI-language (ADNI-LAN), and ADNI-visuospatial (ADNI-VS) composite scores. TBM parameters, including measure 1, which represents average within a statistically defined region-of-interest inside the temporal lobes and measure 2 which indicates average within an anatomically defined region-of-interest including bilateral temporal lobes were utilized in the current study. Statistical analysis was performed using IBM SPSS Statistics version 26, and Pearson's correlation, Bonferroni's correction, and multiple linear regression were utilized for data analysis. P <0.05 was considered statistically significant.
After screening 800 participants, 270 (151 men, 119 women) were selected for a study with TBM scores and cognition-related assessments at 6, 12, and 24 months. Groups included healthy controls (n=53), MCI (n=158), and Alzheimer's Disease (AD) (n=59). TBM indices correlated with cognitive scores in MCI and AD groups but not healthy controls. Changes in TBM indices and cognitive scores were significantly correlated in MCI and AD groups over 24 months. TBM indices were weak predictors of cognitive decline at all time points.
TBM can help physicians diagnose MCI and AD early. However, TBM could not strongly predict cognitive functions decline at all time points.
基于文献，张量形态计量学（TBM）参数与记忆、学习、语言能力和执行功能等神经认知功能相关。本研究旨在评估 TBM 指数与执行功能、记忆、语言和视空间能力之间的相关性，并评估 TBM 在阿尔茨海默病神经影像学倡议（ADNI）中阿尔茨海默病连续体和轻度认知障碍（MCI）个体中的临床诊断价值。
作者使用了 ADNI 记忆（ADNI-MEM）、ADNI 执行功能（ADNI-EF）、ADNI 语言（ADNI-LAN）和 ADNI 视空间（ADNI-VS）综合评分。本研究中使用了 TBM 参数，包括代表颞叶内统计定义感兴趣区内平均的度量 1 和表示包括双侧颞叶在内的解剖定义感兴趣区内平均的度量 2。使用 IBM SPSS Statistics 版本 26 进行统计分析，采用 Pearson 相关、Bonferroni 校正和多元线性回归进行数据分析。P<0.05 被认为具有统计学意义。
在筛选了 800 名参与者后，有 270 名（151 名男性，119 名女性）参与者具有 TBM 评分和认知相关评估，时间点分别为 6、12 和 24 个月。这些参与者分为健康对照组（n=53）、MCI 组（n=158）和阿尔茨海默病（AD）组（n=59）。TBM 指数与 MCI 和 AD 组的认知评分相关，但与健康对照组无关。在 24 个月的时间内，TBM 指数和认知评分的变化在 MCI 和 AD 组中显著相关。TBM 指数是 MCI 和 AD 组所有时间点认知下降的弱预测指标。
TBM 可以帮助医生早期诊断 MCI 和 AD。然而，TBM 并不能在所有时间点都强烈预测认知功能的下降。
