University of Tuebingen, Department of Clinical Psychology and Psychotherapy, Germany.
University of Freiburg, Department of Clinical Psychology and Psychotherapy, Germany.
Appetite. 2024 Dec 1;203:107682. doi: 10.1016/j.appet.2024.107682. Epub 2024 Sep 18.
Attentional biases towards food play an important role in the pathology of binge eating disorder (BED). Later stage electrophysiological potentials (P300, late positive potential) present promising markers of motivated attention with high temporal, albeit low spatial resolution. Complementing this, the N2pc is an earlier-latency component providing the possibility of more directly analyzing visuospatial attention. Therefore, we tested a group with BED (N = 60), as well as an overweight (OW; N = 28) and normal weight (NW; N = 30) group without BED in a Go/No-Go paradigm using food and nonfood distractor images. Only the OW group in exclusively the Go trials displayed a stronger spatial attention allocation towards nonfood distractors as evidenced by an increased N2pc amplitude. In the P300's time window, the OW group displayed no attentional bias towards food and the NW group only did so in the absence of a target. Solely the BED group allocated more motivated attention towards food distractors both in Go and No-Go trials. In the following late positive potential (LPP), the OW group exhibited a general attentional bias towards food distractors, while the BED group only did so in the absence of a target. These results are discussed in light of the incentive sensitization theory and a potential early attentional suppression of potent distractors.
注意力对食物的偏见在暴食症（BED）的发病机制中起着重要作用。后期电生理电位（P300、晚正电位）是动机注意力的有前途的标志物，具有高时间分辨率，尽管空间分辨率较低。作为补充，N2pc 是一种较早潜伏期的成分，提供了更直接分析视空间注意力的可能性。因此，我们在 Go/No-Go 范式中测试了一组 BED 患者（N=60），以及一组超重（OW；N=28）和正常体重（NW；N=30）患者，这些患者没有 BED，使用食物和非食物分心物图像。只有 OW 组在仅 Go 试验中显示出对非食物分心物更强的空间注意力分配，表现为 N2pc 振幅增加。在 P300 的时间窗口中，OW 组对食物没有注意力偏见，而 NW 组只有在没有目标的情况下才会这样。只有 BED 组在 Go 和 No-Go 试验中都对食物分心物表现出更多的动机注意力。在随后的晚正电位（LPP）中，OW 组对食物分心物表现出普遍的注意力偏见，而 BED 组只有在没有目标的情况下才会这样。这些结果是根据激励敏感化理论和对有效分心物的潜在早期注意力抑制来讨论的。
