Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan; National Laboratory Animal Center, National Applied Research Laboratories, Taipei 115, Taiwan.
Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan; National Laboratory Animal Center, National Applied Research Laboratories, Taipei 115, Taiwan; Graduate Institute of Biomedical Sciences, Neuroscience and Brain Disease Center, China Medical University, Taichung 404, Taiwan.
Gen Comp Endocrinol. 2024 Nov 1;358:114613. doi: 10.1016/j.ygcen.2024.114613. Epub 2024 Sep 19.
Zebrafish sex chromosomes have been identified in the wild Nadia (NA) strain, and its sex determination belongs to the female-heterogametic ZZ/ZW system. Here, we investigate the correlation between ZZ/ZW sex chromosomes in the NA strain with sex-related factors, and sort out the complicated process of sex determination in zebrafish. Two phases exist during zebrafish sex differentiation. In the first phase, ZW gonads differentiate into juvenile ovary while ZZ gonads remain indifferent. In the second phase, ZW gonads either continue ovary development or undergo female-to-male transition, while ZZ gonads undergo direct male development. The W chromosome may contribute to the first phase while the abundance of germ cells and other factors may be involved in the second phase of sex differentiation in zebrafish.
斑马鱼的性染色体在野生型 Nadia (NA) 品系中已被鉴定出来，其性别决定属于雌性异型 ZZ/ZW 系统。在这里，我们研究了 NA 品系中 ZZ/ZW 性染色体与性别相关因素之间的相关性，并梳理了斑马鱼性别决定的复杂过程。斑马鱼的性别分化存在两个阶段。在第一阶段，ZW 性腺分化为幼年卵巢，而 ZZ 性腺保持中性。在第二阶段，ZW 性腺要么继续卵巢发育，要么经历雌性到雄性的转变，而 ZZ 性腺则直接发育为雄性。W 染色体可能有助于第一阶段，而生殖细胞的丰度和其他因素可能参与了斑马鱼性别分化的第二阶段。
