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浅析脂肪细胞去分化的分子变化及其未来的研究机遇。

Insights into the molecular changes of adipocyte dedifferentiation and its future research opportunities.

机构信息

Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

出版信息

J Lipid Res. 2024 Nov;65(11):100644. doi: 10.1016/j.jlr.2024.100644. Epub 2024 Sep 18.

DOI:10.1016/j.jlr.2024.100644
PMID:39303983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11550672/
Abstract

Recent studies have challenged the traditional belief that mature fat cells are irreversibly differentiated and revealed they can dedifferentiate into fibroblast-like cells known as dedifferentiated fat (DFAT) cells. Resembling pluripotent stem cells, DFAT cells hold great potential as a cell source for stem cell therapy. However, there is limited understanding of the specific changes that occur following adipocyte dedifferentiation and the detailed regulation of this process. This review explores the epigenetic, genetic, and phenotypic alterations associated with DFAT cell dedifferentiation, identifies potential targets for clinical regulation and discusses the current applications and challenges in the field of DFAT cell research.

摘要

最近的研究挑战了成熟脂肪细胞不可逆分化的传统观念，揭示了它们可以去分化为成纤维样细胞，称为去分化脂肪（DFAT）细胞。DFAT 细胞类似于多能干细胞，作为干细胞治疗的细胞来源具有巨大的潜力。然而，人们对脂肪细胞去分化后发生的具体变化以及这一过程的详细调控知之甚少。本综述探讨了与 DFAT 细胞去分化相关的表观遗传、遗传和表型改变，确定了临床调控的潜在靶点，并讨论了 DFAT 细胞研究领域的当前应用和挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e23/11550672/f33918d13f9f/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e23/11550672/492e10e13bd0/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e23/11550672/6bdcef6c19b9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e23/11550672/c00f01ff27a1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e23/11550672/78b394dacea8/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e23/11550672/f33918d13f9f/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e23/11550672/492e10e13bd0/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e23/11550672/6bdcef6c19b9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e23/11550672/c00f01ff27a1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e23/11550672/78b394dacea8/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e23/11550672/f33918d13f9f/gr4.jpg

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Evaluating the Efficacy of Dedifferentiated Fat Cells (DFATs) vs Adipose-Derived Stem Cells (ASCs) in Enhancing the Viability of Fat Grafts.
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A cell transcriptomic profile provides insights into adipocytes of porcine mammary gland across development.细胞转录组图谱为猪乳腺发育过程中的脂肪细胞提供了深入见解。
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