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蝰蛇咬伤治疗过程中发生心肌梗死:病例报告。

Myocardial infarction during treatment of Crotalinae envenomation: A case report.

机构信息

University of Arizona College of Medicine - Tucson, University of Arizona, Tucson, AZ, USA.

Arizona Poison and Drug Information Center, University of Arizona, Tucson, AZ, USA.

出版信息

Toxicon. 2024 Nov 6;250:108105. doi: 10.1016/j.toxicon.2024.108105. Epub 2024 Sep 19.

Abstract

While myocardial infarction is a rare, but known, potential side effect of snakebite envenomation, snake antivenom has thus far not been associated with any cardiovascular adverse events. We report the case of a 71-year-old man who developed an anterolateral MI during administration of Crotalidae immune F(ab')2 (equine) (ANAVIP), given as treatment for Crotalidae envenomation. The patient required cardiac catheterization with stenting of the left anterior descending artery and was discharged two days later on long-term clopidogrel and aspirin. Treatment of MI in the setting of envenomation should mirror typical management, with consideration of additional antivenom if the ischemia is determined to be venom-induced. Clinicians should have a high index of suspicion for patients with chest pain after snake envenomation or administration of antivenom.

摘要

虽然心肌梗死是蛇咬伤中毒的一种罕见但已知的潜在副作用,但蛇抗蛇毒血清迄今为止与任何心血管不良事件都没有关联。我们报告了一例 71 岁男性的病例,他在接受 Crotalidae 免疫 F(ab')2(马)(ANAVIP)治疗时发生前侧壁心肌梗死,该患者因 Crotalidae 中毒而接受治疗。患者需要进行经导管冠状动脉成形术,并在前降支置入支架,两天后出院,长期服用氯吡格雷和阿司匹林。在中毒的情况下治疗心肌梗死应与典型的治疗方法相似,如果确定缺血是由毒液引起的,则应考虑额外使用抗蛇毒血清。对于蛇咬伤或使用抗蛇毒血清后出现胸痛的患者,临床医生应保持高度警惕。

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