School of Instrumentation and Optoelectronics Engineering, Beihang University, Beijing 100191, China; Ningbo Institute of Technology, Beihang University, Ningbo 315800, China; Institute of Large-scale Scientific Facility and Centre for Zero Magnetic Field Science, Beihang University, Beijing 100191, China.
Ningbo Institute of Technology, Beihang University, Ningbo 315800, China; Zhejiang Engineering Research Center of Precision Electromagnetic Control Technology and Equipment, Ningbo 315800, China.
Neuroimage. 2024 Oct 15;300:120842. doi: 10.1016/j.neuroimage.2024.120842. Epub 2024 Sep 18.
Magnetoencephalography based on optically pumped magnetometers can passively detect the ultra-weak brain magnetic field signals, which has significant clinical application prospects for the diagnosis and treatment of cerebral disorders. This paper proposes a brain magnetic signal measurement method on the basis of the active-passive coupling magnetic shielding strategy and helmet-mounted detection array, which has lower cost and comparable performance over the existing ones. We first utilized the spatially-grid constrained coils and biplanar coils with proportion-integration-differentiation controller with tracking differentiator to ensure a near-zero and stable magnetic field environment with large uniform region. Subsequently, we implemented the brain magnetic signal measurement with the subject randomly moving fingers through tapping a keyboard and with the condition of opening and closing the eyes. Effectively induced brain magnetic signals were detected at the motor functional area and occipital lobe area in the two experiments, respectively. The proposed method will contribute to the development of functional brain imaging.
基于光泵磁强计的脑磁图可以被动地检测超弱脑磁场信号，在脑疾病的诊断和治疗方面具有重要的临床应用前景。本文提出了一种基于主动-被动耦合磁屏蔽策略和头盔式检测阵列的脑磁信号测量方法，该方法具有更低的成本和与现有方法相当的性能。我们首先利用空间网格约束线圈和具有比例积分微分控制器的双平面线圈，并采用跟踪微分器来确保具有大均匀区域的近零且稳定的磁场环境。随后，我们通过让被试随机移动手指敲击键盘以及睁眼和闭眼两种条件，实现了脑磁信号的测量。在这两个实验中，分别在运动功能区和枕叶区有效地检测到了有效诱导的脑磁信号。该方法将有助于功能性脑成像的发展。
