Chemistry Department, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Faculty of Postgraduate Studies for Nanotechnology, Cairo University, Giza, 12613, Egypt.
Sci Rep. 2024 Sep 20;14(1):21972. doi: 10.1038/s41598-024-71341-2.
The recent investigation targets to use adapted carbon paste (CP) with copper nanoparticles (CuNs) operating in a phosphate buffer (PBS) medium with a pH range of 5.0-8.0, to synthesize a novel, susceptible, and simple electrochemical sensor for the detection of one of the most important drugs, vitamin B. Copper (Cu) is one of the most three common essential trace elements found in the bodies of both humans and animals, along with iron and zinc for all crucial physiological and biochemical functions. Its properties, which are assessed using a variety of methods including scanning electron microscopy (SEM), cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS), have also drawn a lot of attention recently. We considered the effects of pH, buffer, scan rate, interference, and calibration curve. The susceptible electrode's linear calibration curve encompassed concentration values between 8.88 and 1000.0 µM. The calculated limits of detection and quantification were 32.12 and 107.0 µM, respectively. Furthermore, this method was established in real human urine samples and drug validation which have been shown satisfactory results for vitamin B detection.
最近的研究旨在使用在 pH 值范围为 5.0-8.0 的磷酸盐缓冲液 (PBS) 介质中运行的改良碳糊 (CP) 与铜纳米粒子 (CuNs)，合成一种新型、敏感、简单的电化学传感器，用于检测最重要的药物之一——维生素 B。铜 (Cu) 是人类和动物体内三种最常见的必需微量元素之一，与铁和锌一起参与所有关键的生理和生化功能。最近，人们使用多种方法评估了其性能，包括扫描电子显微镜 (SEM)、循环伏安法 (CV)、差分脉冲伏安法 (DPV) 和电化学阻抗谱 (EIS)。我们考虑了 pH 值、缓冲液、扫描速率、干扰和校准曲线的影响。敏感电极的线性校准曲线涵盖了 8.88 至 1000.0 µM 的浓度值。计算出的检测限和定量限分别为 32.12 和 107.0 µM。此外，该方法已在真实的人尿液样本和药物验证中建立，在维生素 B 检测方面取得了令人满意的结果。
