Liu Jianheng Fox, Jaffrey Samie R
Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY, 10065, USA.
EMBO Rep. 2024 Nov;25(11):4634-4635. doi: 10.1038/s44319-024-00263-x. Epub 2024 Sep 20.
-methyladenosine (mA) is a very rare RNA modification in mammalian mRNA, which occurs in sequences resembling the T-loop of tRNAs and may not have significant effects on gene expression. A new study in this issue now reports that mA is abundant and dynamic in the 3′UTR of mRNAs of dinoflagellates, and could have an important role in post-transcriptional gene expression regulation in these organisms.
N6-甲基腺苷（mA）是哺乳动物mRNA中一种非常罕见的RNA修饰，它出现在类似于tRNA T环的序列中，可能对基因表达没有显著影响。本期的一项新研究报告称，mA在甲藻mRNA的3′非翻译区（3′UTR）中含量丰富且具有动态变化，并且可能在这些生物的转录后基因表达调控中发挥重要作用。
