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脂质分析可识别肥胖儿童和青少年心血管代谢风险的可改变特征。

Lipid profiling identifies modifiable signatures of cardiometabolic risk in children and adolescents with obesity.

作者信息

Huang Yun, Sulek Karolina, Stinson Sara E, Holm Louise Aas, Kim Min, Trost Kajetan, Hooshmand Kourosh, Lund Morten Asp Vonsild, Fonvig Cilius E, Juel Helene Bæk, Nielsen Trine, Ängquist Lars, Rossing Peter, Thiele Maja, Krag Aleksander, Holm Jens-Christian, Legido-Quigley Cristina, Hansen Torben

机构信息

Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.

Steno Diabetes Center Copenhagen, Copenhagen, Denmark.

出版信息

Nat Med. 2025 Jan;31(1):294-305. doi: 10.1038/s41591-024-03279-x. Epub 2024 Sep 20.

DOI:10.1038/s41591-024-03279-x
PMID:39304782
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11750701/
Abstract

Pediatric obesity is a progressive, chronic disease that can lead to serious cardiometabolic complications. Here we investigated the peripheral lipidome in 958 children and adolescents with overweight or obesity and 373 with normal weight, in a cross-sectional study. We also implemented a family-based, personalized program to assess the effects of obesity management on 186 children and adolescents in a clinical setting. Using mass spectrometry-based lipidomics, we report an increase in ceramides, alongside a decrease in lysophospholipids and omega-3 fatty acids with obesity metabolism. Ceramides, phosphatidylethanolamines and phosphatidylinositols were associated with insulin resistance and cardiometabolic risk, whereas sphingomyelins showed inverse associations. Additionally, a panel of three lipids predicted hepatic steatosis as effectively as liver enzymes. Lipids partially mediated the association between obesity and cardiometabolic traits. The nonpharmacological management reduced levels of ceramides, phospholipids and triglycerides, indicating that lowering the degree of obesity could partially restore a healthy lipid profile in children and adolescents.

摘要

儿童肥胖是一种渐进性的慢性疾病，可导致严重的心脏代谢并发症。在一项横断面研究中，我们调查了958名超重或肥胖儿童及青少年以及373名体重正常儿童及青少年的外周脂质组。我们还实施了一项基于家庭的个性化计划，以评估肥胖管理对临床环境中186名儿童及青少年的影响。使用基于质谱的脂质组学方法，我们报告称，随着肥胖代谢，神经酰胺增加，同时溶血磷脂和ω-3脂肪酸减少。神经酰胺、磷脂酰乙醇胺和磷脂酰肌醇与胰岛素抵抗和心脏代谢风险相关，而鞘磷脂则呈负相关。此外，一组三种脂质预测肝脂肪变性的效果与肝酶一样有效。脂质部分介导了肥胖与心脏代谢特征之间的关联。非药物管理降低了神经酰胺、磷脂和甘油三酯的水平，表明降低肥胖程度可部分恢复儿童及青少年健康的脂质谱。

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8
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