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角质板和听觉毛细胞连接处的丝状肌动蛋白受肌动蛋白解聚因子（ADF）和丝切蛋白调节，以实现正常的静纤毛束模式形成和维持。

F-actin in the cuticular plate and junctions of auditory hair cells is regulated by ADF and cofilin to allow for normal stereocilia bundle patterning and maintenance.

作者信息

McGrath Jamis, Hawbaker Katelin, Perrin Benjamin J

机构信息

Department of Biology, Indiana University - Indianapolis, Indianapolis, Indiana, USA.

出版信息

Cytoskeleton (Hoboken). 2025 May;82(5):302-310. doi: 10.1002/cm.21933. Epub 2024 Sep 21.

DOI:10.1002/cm.21933
PMID:39305224
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11925801/
Abstract

Auditory hair cells, which convert sound-induced vibrations in the inner ear into neural signals, depend on multiple actin populations for normal function. Stereocilia are mechanosensory protrusions formed around a core of linear, crosslinked F-actin. They are anchored in the cuticular plate, which predominantly consists of randomly oriented actin filaments. A third actin population is found near hair cell junctions, consisting of both parallel and branched filaments. Actin depolymerizing factor (ADF) and cofilin-1 (CFL1) proteins disassemble actin filaments and are required to regulate F-actin in stereocilia, but their effect on cuticular plate and junctional actin populations is unclear. Here, we show that loss of ADF and CFL1 disrupts the patterning of stereocilia into orderly bundles and that this phenotype correlates with defective development of the cuticular plate and junctional actin populations. ADF/CFL1 continue to regulate these actin populations in mature cells, which is necessary for long-term maintenance of hair cell morphology.

摘要

听觉毛细胞将内耳中声音引起的振动转化为神经信号，其正常功能依赖于多种肌动蛋白群体。静纤毛是围绕线性交联F-肌动蛋白核心形成的机械感觉突起。它们锚定在角质板中，角质板主要由随机取向的肌动蛋白丝组成。在毛细胞连接处附近发现了第三种肌动蛋白群体，由平行和分支的丝组成。肌动蛋白解聚因子（ADF）和丝切蛋白-1（CFL1）蛋白可分解肌动蛋白丝，是调节静纤毛中F-肌动蛋白所必需的，但它们对角质板和连接肌动蛋白群体的影响尚不清楚。在这里，我们表明ADF和CFL1的缺失会破坏静纤毛形成有序束状的模式，并且这种表型与角质板和连接肌动蛋白群体的发育缺陷相关。ADF/CFL1在成熟细胞中继续调节这些肌动蛋白群体，这是毛细胞形态长期维持所必需的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c6e/12063515/664e9733902f/CM-82-302-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c6e/12063515/5b80ce33e5b7/CM-82-302-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c6e/12063515/9dc7c1ae9772/CM-82-302-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c6e/12063515/3fbd8eeefe7f/CM-82-302-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c6e/12063515/2624b66fd982/CM-82-302-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c6e/12063515/664e9733902f/CM-82-302-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c6e/12063515/5b80ce33e5b7/CM-82-302-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c6e/12063515/9dc7c1ae9772/CM-82-302-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c6e/12063515/3fbd8eeefe7f/CM-82-302-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c6e/12063515/2624b66fd982/CM-82-302-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c6e/12063515/664e9733902f/CM-82-302-g005.jpg

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The integrity of cochlear hair cells is established and maintained through the localization of Dia1 at apical junctional complexes and stereocilia.
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Cell Death Dis. 2020 Jul 16;11(7):536. doi: 10.1038/s41419-020-02743-z.
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Critical role of spectrin in hearing development and deafness. spectrin 在听力发育和耳聋中的关键作用。
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LMO7 deficiency reveals the significance of the cuticular plate for hearing function.LMO7 缺失揭示了表皮板对于听力功能的重要性。
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