Hajinejad Mehrdad, Far Bahareh Farasati, Gorji Ali, Sahab-Negah Sajad
Qaen Faculty of Medical Sciences, Birjand University of Medical Sciences, Birjand, Iran.
Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Feb;398(2):1391-1402. doi: 10.1007/s00210-024-03415-x. Epub 2024 Sep 21.
Glial cells play a critical role in the healthy and diseased phases of the central nervous system (CNS). CNS diseases involve a wide range of pathological conditions characterized by poor recovery of neuronal function. Glial cell-related target therapies are progressively gaining interest in inhibiting secondary injury-related death. Modulation of the extracellular matrix by artificial scaffolds plays a critical role in the behavior of glial cells after injury. Among numerous types of scaffolds, self-assembling peptides (SAPs) notably give attention to the design of a proper biophysical and biomechanical microenvironment for cellular homeostasis and tissue regeneration. Implementing SAPs in an injured brain can induce neural differentiation in transplanted stem cells, reducing inflammation and inhibiting glial scar formation. In this review, we investigate the recent findings to elucidate the pivotal role of SAPs in orchestrating the most pivotal secondary response following CNS injury. Notably, we explore their impact on the activation of glial cells and their modulatory effects on microglial and astrocytic polarization.
神经胶质细胞在中枢神经系统（CNS）的健康和患病阶段都起着关键作用。中枢神经系统疾病涉及广泛的病理状况，其特征是神经元功能恢复不佳。与神经胶质细胞相关的靶向治疗在抑制继发性损伤相关死亡方面越来越受到关注。人工支架对细胞外基质的调节在损伤后神经胶质细胞的行为中起关键作用。在众多类型的支架中，自组装肽（SAPs）特别关注为细胞稳态和组织再生设计合适的生物物理和生物力学微环境。在受损大脑中应用自组装肽可诱导移植干细胞的神经分化，减轻炎症并抑制神经胶质瘢痕形成。在本综述中，我们研究了最近的发现，以阐明自组装肽在协调中枢神经系统损伤后最关键的继发性反应中的关键作用。值得注意的是，我们探讨了它们对神经胶质细胞激活的影响以及对小胶质细胞和星形胶质细胞极化的调节作用。
