Bissen-Miyajima Hiroko, Ota Yuka, Minami Keiichiro, Taira Yoko, Takemura Ryo
Department of Ophthalmology, Tokyo Dental College Suidobashi Hospital, Kandamisaki-cho 2-9-18, Chiyoda-ku, Tokyo, 101-0061, Japan.
Ryuundo Eye Clinic, Shiki, Saitama, Japan.
Ophthalmol Ther. 2024 Nov;13(11):2919-2929. doi: 10.1007/s40123-024-01035-5. Epub 2024 Sep 21.
The aim of this prospective and comparative study was to investigate the association of perimetry parameters on visual acuity and contrast sensitivity in primary open-angle glaucoma (POAG) eyes with diffractive extended depth-of-focus (EDoF) and monofocal intraocular lenses (IOLs).
In cataract eyes with medicinally controlled POAG with no defects in the central visual field and mean deviation (MD) values of - 10 dB or better, EDoF and monofocal IOLs with the same platform except for echelette optics for EDoF were implanted in 22 and 24 eyes, respectively. Corrected distance visual acuity (CDVA), contrast sensitivity at 3 to 18 cycles per degree (cpd), and automated perimetry using 30-2 and 10-2 Swedish Interactive Threshold Algorithm programs were examined 3 months postoperatively. The influences of perimetry parameters including MD, foveal sensitivity (FS), and the means of the central four points (central MD and central FS) on CDVA and contrast sensitivity were evaluated using linear and multiple regression analyses.
In POAG eyes with EDoF IOLs, contrast sensitivities at 12 and 18 cpd were associated with 30-2 and 10-2 perimetry parameters. In POAG eyes with monofocal IOLs, associations of 30-2 parameters were found in CDVA and 3-cpd contrast sensitivity.
The visual function of POAG eyes with EDoF IOLs was associated with perimetry parameters in high spatial frequency contrast sensitivity, which was different from that of POAG eyes with monofocal IOL.
Japan Registry for Clinical Research: jRCTs032200218.
本前瞻性比较研究的目的是调查原发性开角型青光眼（POAG）患者中，采用衍射型扩展景深（EDoF）人工晶状体和单焦点人工晶状体（IOL）时，视野检查参数与视力及对比敏感度之间的关联。
在药物控制的POAG白内障眼中，若中央视野无缺损且平均偏差（MD）值为-10 dB或更佳，则分别将22只眼和24只眼植入EDoF人工晶状体和除用于EDoF的小阶梯光栅光学元件外具有相同平台的单焦点IOL。术后3个月检查矫正远视力（CDVA）、每度3至18周/度（cpd）的对比敏感度，以及使用30-2和10-2瑞典交互式阈值算法程序进行的自动视野检查。使用线性和多元回归分析评估包括MD、黄斑敏感度（FS）以及中央四点平均值（中央MD和中央FS）等视野检查参数对CDVA和对比敏感度的影响。
在植入EDoF IOL的POAG眼中，12和18 cpd的对比敏感度与30-2和10-2视野检查参数相关。在植入单焦点IOL的POAG眼中，在CDVA和3 cpd对比敏感度中发现了30-2参数的关联。
植入EDoF IOL的POAG眼的视觉功能与高空间频率对比敏感度的视野检查参数相关，这与植入单焦点IOL的POAG眼不同。
日本临床研究注册中心：jRCTs032200218。
