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引入一种用于精神分裂症的新严重程度说明符:概念框架及临床意义。

Introducing a new severity specifier for schizophrenia: conceptual framework and clinical implications.

作者信息

Gadelha Ary, Biokino Renan M, Lorencetti Pedro, Crossley Nicolas A, Bordini Daniela, Massuda Raffael

机构信息

Departamento de Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP, Brazil. Programa de Esquizofrenia, EPM/UNIFESP, São Paulo, SP, Brazil. Laboratório Interdisciplinar de Neurociências Clínicas, Departamento de Psiquiatria, EPM/UNIFESP, São Paulo, SP, Brazil.

Departamento de Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP, Brazil. Programa de Esquizofrenia, EPM/UNIFESP, São Paulo, SP, Brazil.

出版信息

Braz J Psychiatry. 2024;46:e20243722. doi: 10.47626/1516-4446-2024-3722. Epub 2024 Sep 19.

Abstract

Patients with schizophrenia represent a group heterogeneous in clinical presentation and severity. Although severity has been operationalized in different ways, mostly on a gradient between symptom severity and functional impairment, such approaches are limited in capturing real-world functioning. We suggest adopting the severity model proposed by DSM-5 for autism spectrum disorders. The model defines three levels of severity based on the support required, directly addressing two barriers from previous models: real-world functioning and ease of implementation. Our adapted model includes three new features: first, this severity specifier is global, rather than for each symptom domain; second, the centrality of occupational functioning is emphasized to define the level of support; third, we propose a 1-month timeframe for severity appraisal, standardizing the assessment process. Considering practical utility, we indicate how severity assessment can guide clinical practice towards rehabilitation. Additionally, we outline operational definitions for severity and functioning in schizophrenia, aligned with the premises of our model. Finally, we acknowledge potential limitations, the most relevant being the need for empirical validation. The model is presented to foster discussion. Additional studies will follow to investigate inter-rater reliability and convergent validation with standard measures of symptom and functioning severity.

摘要

精神分裂症患者在临床表现和严重程度上是一个异质性群体。尽管严重程度有不同的衡量方式,大多基于症状严重程度和功能损害之间的梯度,但这些方法在反映现实世界中的功能方面存在局限性。我们建议采用《精神疾病诊断与统计手册》第五版(DSM - 5)为自闭症谱系障碍提出的严重程度模型。该模型根据所需支持定义了三个严重程度级别,直接解决了先前模型存在的两个障碍:现实世界中的功能以及实施的简易性。我们调整后的模型包含三个新特征:第一,这种严重程度说明是全局性的,而非针对每个症状领域;第二,强调职业功能的核心地位以定义支持级别;第三,我们提出以1个月为时间框架进行严重程度评估,使评估过程标准化。考虑到实际效用,我们指出严重程度评估如何能指导临床实践走向康复。此外,我们概述了精神分裂症严重程度和功能的操作性定义,与我们模型的前提一致。最后,我们承认潜在的局限性,最相关的是需要实证验证。提出该模型是为了促进讨论。后续还将开展更多研究,以调查评分者间信度以及与症状和功能严重程度标准测量方法的收敛效度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1345/11773320/f0fbf07c8a81/bjp-46-e20243722-gf01.jpg

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