The Faculty of Medicine, RWTH Aachen University, Rheinisch-Westfälische Technische Hochschule, Aachen, Germany.
Department of Emergency Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Am J Emerg Med. 2024 Dec;86:21-29. doi: 10.1016/j.ajem.2024.08.039. Epub 2024 Sep 3.
Traumatic brain injury (TBI) afflicts 69 million individuals annually, resulting in numerous neuropsychiatric sequelae. Here, we investigate the possible relation between TBI and depression.
an online database search of Pubmed, Scopus, and Web of Science was conducted on November 3rd, 2023 for observational studies investigating post-TBI depressive symptoms incidence or comparing the prevalence of depressive symptoms between TBI and non-TBI individuals.
a total of 43 studies were included in our review, 15 of which reported novel cases of depressive symptomology post-TBI and 34 of which compared depressive symptoms in TBI participants with non-TBI participants. Our meta-analysis showed an incidence of 13 % among 724,842 TBI participants, and a relative risk of 2.10 when comparing 106,083 TBI patients to 323,666 non-TBI controls. 11 of the 43 included studies were deemed as having a high risk of bias. Sensitivity analysis showed our findings to be robust and no publication bias was detected using Egger's regression test.
Individuals suffering from TBI are almost twice as likely to develop depressive symptomology compared to non-TBI individuals.
创伤性脑损伤（TBI）每年影响 6900 万人，导致许多神经精神后遗症。在这里，我们研究 TBI 与抑郁症之间可能存在的关系。
我们于 2023 年 11 月 3 日在 Pubmed、Scopus 和 Web of Science 上进行了在线数据库检索，以调查观察性研究中 TBI 后抑郁症状的发生率，或比较 TBI 患者和非 TBI 患者之间抑郁症状的患病率。
我们的综述共纳入了 43 项研究，其中 15 项报告了 TBI 后新出现的抑郁症状病例，34 项比较了 TBI 参与者和非 TBI 参与者的抑郁症状。我们的荟萃分析显示，在 724842 名 TBI 参与者中，有 13%的人出现抑郁症状，在将 106083 名 TBI 患者与 323666 名非 TBI 对照者进行比较时，相对风险为 2.10。43 项纳入研究中有 11 项被认为存在高偏倚风险。敏感性分析表明，我们的研究结果是稳健的，Egger 回归检验未发现发表偏倚。
与非 TBI 个体相比，TBI 患者出现抑郁症状的可能性几乎高出一倍。
