Sanquan College of Xinxiang Medical University, Xinxiang, 453000, China.
Sanquan College of Xinxiang Medical University, Xinxiang, 453000, China.
J Ethnopharmacol. 2024 Jan 10;318(Pt B):116957. doi: 10.1016/j.jep.2023.116957. Epub 2023 Aug 6.
Epimedium koreanum Nakai (E. koreanum), a member of the genus Epimedium in the family Berberidaceae, is a well-known and well-liked traditional herb used as a "kidney tonic". For thousands of years, it has been utilized for renal yang deficiency, impotence, spermatorrhea, impotence, weakness of tendons and bones, rheumatic paralysis and discomfort, numbness, and constriction.
The paper aims to comprehensively in-depth, and methodically review the most recent research on the traditional uses, phytochemistry, pharmacology, and toxicity of E. koreanum.
Scientific databases including Web of Science, PubMed, Google Scholar, Elsevier, Springer, ScienceDirect, Baidu Scholar, and CNKI and medicine books in China were searched for relevant information on E. koreanum.
In traditional uses, E. koreanum is frequently used to treat various diseases like erectile dysfunction, infertility, rheumatoid arthritis, osteoporosis, asthma, kidney-yang deficiency syndrome, etc. To date, more than 379 compounds have been discovered from various parts of E. koreanum, including flavonoids, lignans, organic acids, terpenoids, hydrocarbons, dihydrophenanthrene derivatives, alkaloids, and others. Research has revealed that the compounds and crude extracts have a wide range of pharmacological effects on the reproductive, cardiovascular, and nervous systems, as well as anti-osteoporosis, anti-tumor, antioxidant, anti-inflammatory, immunomodulatory, hepatoprotective, and antiviral properties. Besides, the crude extracts show potential hepatotoxicity.
Based on recent domestic and international research investigations, E. koreanum contains a wealth of chemical components with pronounced pharmacological activities. Its traditional uses are numerous, and the majority of these traditional uses have been supported by contemporary pharmacological investigations. Crude extracts, on the other hand, can result in hepatotoxicity. Therefore, additional in vivo and in vitro experimental research on the pharmacology and toxicology of E. koreanum are required in the future to assess its safety and efficacy. This will give a firmer scientific foundation for its safe application and the development of new drugs in the future.
淫羊藿（Epimedium koreanum Nakai），小檗科淫羊藿属植物，是一种众所周知且广受欢迎的传统草药，用作“补肾药”。几千年来，它一直被用于治疗肾阳虚、阳痿、遗精、阳痿、筋骨虚弱、风湿性瘫痪和不适、麻木和收缩。
本文旨在全面、深入、系统地综述淫羊藿的传统用途、植物化学、药理学和毒性的最新研究。
科学数据库，包括 Web of Science、PubMed、Google Scholar、Elsevier、Springer、ScienceDirect、百度学术和中国医学书籍，用于搜索淫羊藿的相关信息。
在传统用途中，淫羊藿常用于治疗各种疾病，如勃起功能障碍、不育症、类风湿性关节炎、骨质疏松症、哮喘、肾阳虚综合征等。迄今为止，已从淫羊藿的各个部位发现了 379 多种化合物，包括黄酮类、木脂素类、有机酸类、萜类、烃类、二氢菲衍生物、生物碱类等。研究表明，这些化合物和粗提取物对生殖、心血管和神经系统以及抗骨质疏松症、抗肿瘤、抗氧化、抗炎、免疫调节、保肝和抗病毒作用具有广泛的药理作用。此外，粗提取物显示出潜在的肝毒性。
基于最近国内外的研究调查，淫羊藿含有丰富的具有明显药理活性的化学成分。它的传统用途很多，其中大部分传统用途都得到了当代药理研究的支持。然而，粗提取物可能导致肝毒性。因此，未来需要对淫羊藿的药理学和毒理学进行更多的体内和体外实验研究，以评估其安全性和有效性。这将为其安全应用和未来新药的开发提供更坚实的科学基础。
