College of Pharmaceutical Engineering of Traditional Chinese Medicine (TCM), Tianjin University of TCM, Tianjin, 301617, China.
College of Pharmaceutical Engineering of Traditional Chinese Medicine (TCM), Tianjin University of TCM, Tianjin, 301617, China; Tianjin Key Laboratory of Intelligent and Green Pharmaceuticals for TCM, Tianjin, 301617, China; State Key Laboratory of Chinese Medicine Modernization, Tianjin University of TCM, Tianjin, 301617, China.
Talanta. 2025 Jan 1;281:126918. doi: 10.1016/j.talanta.2024.126918. Epub 2024 Sep 20.
The pervasive threat of foodborne pathogenic bacteria necessitates advancements in rapid and reliable detection methods. Traditional approaches suffer from significant limitations including prolonged processing times, limited sensitivity and specificity. This review comprehensively examines the integration of metal organic frameworks (MOFs) with sensor technologies for the enhanced detection of foodborne pathogens. MOFs, with their unique properties such as high porosity, tunable pore sizes, and ease of functionalization, offer new avenues for sensor enhancement. This paper provides a comprehensive analysis of recent developments in MOFs-based sensors, particularly focusing on electrochemical, fluorescence, colorimetric, and surface-enhanced Raman spectroscopy sensors. We have provided a detailed introduction for the operational principles of these sensors, highlighting the role of MOFs play in enhancing their performance. Comparative analyses demonstrate MOFs' superior capabilities in enhancing signal response, reducing response time, and expanding detection limits. This review culminates in presenting MOFs as transformative materials in the detection of foodborne pathogens, paving the way for their broader application in ensuring food safety.
食源性致病菌的普遍威胁需要快速可靠的检测方法的进步。传统方法存在显著的局限性，包括处理时间长、灵敏度和特异性有限。本综述全面考察了金属有机骨架（MOFs）与传感器技术的结合，用于增强食源性致病菌的检测。MOFs 具有独特的性质，如高孔隙率、可调节的孔径和易于功能化，为传感器增强提供了新途径。本文对基于 MOFs 的传感器的最新发展进行了全面分析，特别侧重于电化学、荧光、比色和表面增强拉曼光谱传感器。我们详细介绍了这些传感器的工作原理，强调了 MOFs 在增强其性能方面的作用。比较分析表明，MOFs 在增强信号响应、缩短响应时间和扩大检测限方面具有优越的性能。本综述的结论是，MOFs 是食源性致病菌检测中的变革性材料，为它们在确保食品安全方面的更广泛应用铺平了道路。
