Department of Epidemiology, Brown University School of Public Health, 121 South Main Street, Box G-S-121-2, Providence, RI 02912, USA.
Department of Health, Behavior, and Society, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA; Division of General Internal Medicine, Warren Alpert Medical School, Brown University, Providence, RI, USA; Center of Biomedical Research Excellent on Opioids and Overdose, Rhode Island Hospital, Providence, RI, USA.
Drug Alcohol Depend. 2024 Nov 1;264:112446. doi: 10.1016/j.drugalcdep.2024.112446. Epub 2024 Sep 12.
Illicitly manufactured fentanyl accounts for a majority of overdose fatalities in the US. Research has demonstrated that fentanyl test strips (FTS) help people who use drugs (PWUD) avoid unintended exposure to fentanyl and overdose. This study assesses characteristics associated with FTS use among PWUD in Rhode Island. Such findings may shed light on whether there are subgroups of PWUD who are less likely to be using FTS and therefore may benefit from their use.
From September 2020 - February 2023, participants were recruited to participate in RAPIDS, a clinical trial assessing whether FTS provision can reduce overdose rates. Baseline data were used to assess correlates of lifetime FTS use through bivariable and multivariable analyses. We also examined drug testing patterns relating to FTS use in the past month.
Of 509 people enrolled, 376 (73.9 %) had heard of FTS before enrollment. Among this group, 189 (50.3 %) reported lifetime FTS use and 98 (26.1 %) reported use in the last month. In bivariable analyses, lifetime injection drug use, responding to an overdose, and drug selling were associated with FTS use. Solitary drug use was not associated with FTS uptake. In the multivariable analysis, gender and lifetime naloxone administration were associated with FTS use. Of those who used FTS in the past month, 76.5 % had at least one test that was positive for fentanyl.
We found high uptake of FTS use among PWUD in Rhode Island. Our results also suggest a need for targeted outreach to increase FTS uptake among sub-groups of PWUD.
The Rhode Island Prescription and Illicit Drug Study is a registered clinical trial, NCT043722838.
在美国，非法制造的芬太尼导致了大多数过量死亡事件。研究表明，芬太尼检测条（FTS）有助于吸毒者（PWUD）避免意外接触芬太尼和过量用药。本研究评估了罗德岛 PWUD 使用 FTS 的特征。这些发现可能揭示了哪些亚组的 PWUD 不太可能使用 FTS，因此可能受益于 FTS 的使用。
从 2020 年 9 月至 2023 年 2 月，招募参与者参加 RAPIDS 研究，该研究评估了提供 FTS 是否可以降低过量用药率。通过单变量和多变量分析，使用基线数据评估了一生中使用 FTS 的相关性。我们还检查了过去一个月与 FTS 使用相关的药物检测模式。
在 509 名入组者中，376 名（73.9%）在入组前听说过 FTS。在这一组中，189 名（50.3%）报告一生中使用过 FTS，98 名（26.1%）报告在过去一个月中使用过 FTS。在单变量分析中，终生注射吸毒、对过量用药的反应和毒品贩卖与 FTS 的使用有关。单独吸毒与 FTS 的使用无关。在多变量分析中，性别和一生中使用纳洛酮与 FTS 的使用有关。在过去一个月中使用 FTS 的人中，有 76.5%的人至少有一次检测结果呈芬太尼阳性。
我们发现罗德岛 PWUD 中 FTS 的使用率很高。我们的结果还表明，需要针对特定人群进行宣传，以提高 PWUD 中 FTS 的使用率。
罗德岛处方和非法药物研究是一项已注册的临床试验，NCT043722838。
