Suppr超能文献

迷幻剂:对啮齿类动物回忆性厌恶记忆和恐惧/焦虑表达的影响的综述。

Psychedelics: A review of their effects on recalled aversive memories and fear/anxiety expression in rodents.

机构信息

Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

出版信息

Neurosci Biobehav Rev. 2024 Dec;167:105899. doi: 10.1016/j.neubiorev.2024.105899. Epub 2024 Sep 19.

Abstract

Threatening events and stressful experiences can lead to maladaptive memories and related behaviors. Existing treatments often fail to address these issues linked to anxiety/stress-related disorders effectively. This review identifies dose ranges associated with specific actions across various psychedelics. We examined psilocybin/psilocin, lysergic acid diethylamide (LSD), N,N-dimethyltryptamine (DMT), mescaline, 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), serotonin 2 A/2 C agonists (e.g., DOI) and 3,4-methylenedioxymethamphetamine (MDMA) on aversive memory extinction and reconsolidation, learned fear, anxiety, and locomotion in rodents. Nearly 400 studies published since 1957 were reviewed. Psychedelics often show biphasic effects on locomotion at doses that enhance extinction learning/retention, impair memory reconsolidation, or reduce learned fear and anxiety. Emerging evidence suggests a dissociation between their prospective benefits and locomotor effects. Under-explored aspects include sex differences, susceptibility to interference as memories age and generalize, repeated treatments, and immediate vs. delayed changes. Validating findings in traumatic-like memory and maladaptive fear/anxiety models is essential. Understanding how psychedelics modulate threat responses and post-retrieval memory processes in rodents may inform drug development and human studies, improving therapeutic approaches for related psychiatric conditions.

摘要

威胁性事件和压力性经历可能导致适应不良的记忆和相关行为。现有的治疗方法往往无法有效地解决与焦虑/应激相关障碍相关的这些问题。这篇综述确定了各种迷幻剂与特定行为相关的剂量范围。我们检查了裸盖菇素/裸盖菇素、麦角酸二乙基酰胺 (LSD)、N,N-二甲基色胺 (DMT)、三甲氧苯乙胺、5-甲氧基-N,N-二甲基色胺 (5-MeO-DMT)、血清素 2A/2C 激动剂(例如,DOI)和 3,4-亚甲二氧基甲基苯丙胺 (MDMA) 在动物的厌恶记忆消除和再巩固、习得性恐惧、焦虑和运动中的作用。自 1957 年以来发表的近 400 项研究进行了回顾。迷幻剂在增强记忆消除/保留、损害记忆再巩固、或减少习得性恐惧和焦虑的剂量下,对运动表现通常表现出双相作用。新出现的证据表明,它们的预期益处与运动效应之间存在差异。尚未充分研究的方面包括性别差异、随着记忆老化和泛化的易感性、重复治疗以及即时与延迟变化。在创伤样记忆和适应不良的恐惧/焦虑模型中验证发现是至关重要的。了解迷幻剂如何调节啮齿动物的威胁反应和检索后记忆过程,可能为药物开发和人类研究提供信息,从而改善相关精神疾病的治疗方法。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验