ZDHHC13/ZDHHC17 亚家族：从生物学功能到疾病治疗靶点。
The ZDHHC13/ZDHHC17 subfamily: From biological functions to therapeutic targets of diseases.
机构信息
Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, China.
The First Affiliated Hospital, Department of Neurosurgery, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
出版信息
Pharmacol Res. 2024 Nov;209:107418. doi: 10.1016/j.phrs.2024.107418. Epub 2024 Sep 19.
The ZDHHC13/ZDHHC17 subfamily belongs to the zinc finger DHHC-domain containing (ZDHHC) family, including ZDHHC13 and ZDHHC17. Recent studies have shown that the ZDHHC13/ZDHHC17 subfamily is involved in various pathological and physiological processes, including S-palmitoylation, Mg transport, and CALCOCO1-mediated Golgiphagy. Moreover, the ZDHHC13/ZDHHC17 subfamily plays a crucial role in the occurrence and development of many diseases, including Huntington disease (HD), osteoporosis, atopic dermatitis, diabetes, and cancer. In the present review, we describe the distribution, structure, and post-translational modifications (PTMs) of the ZDHHC13/ZDHHC17 subfamily. Moreover, we effectively summarize the biological functions and associated diseases of this subfamily. Given the pleiotropy of the ZDHHC13/ZDHHC17 subfamily, it is imperative to conduct further research on its members to comprehend the pertinent pathophysiological mechanisms and to devise tactics for managing and controlling various diseases.
ZDHHC13/ZDHHC17 亚家族属于含锌指 DHHC 结构域（ZDHHC）家族，包括 ZDHHC13 和 ZDHHC17。最近的研究表明，ZDHHC13/ZDHHC17 亚家族参与多种病理和生理过程，包括 S-棕榈酰化、Mg 转运和 CALCOCO1 介导的高尔基体自噬。此外，ZDHHC13/ZDHHC17 亚家族在许多疾病的发生和发展中起着至关重要的作用，包括亨廷顿病（HD）、骨质疏松症、特应性皮炎、糖尿病和癌症。在本综述中，我们描述了 ZDHHC13/ZDHHC17 亚家族的分布、结构和翻译后修饰（PTMs）。此外，我们还有效地总结了该亚家族的生物学功能和相关疾病。鉴于 ZDHHC13/ZDHHC17 亚家族的多功能性，有必要对其成员进行进一步研究，以了解相关的病理生理机制，并制定策略来管理和控制各种疾病。
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