[ZDHHC介导的蛋白质棕榈酰化在非小细胞肺癌发生发展及免疫逃逸中的研究进展与应用]
[Research Progress and Applications of ZDHHC-mediated Protein Palmitoylation in the Development and Immune Escape of Non-small Cell Lung Cancer].
作者信息
Chen Wangcheng, Pang Lili, Lan Yuemei, Shi Yanhong, Wen Bingbing, Zhang Baihong
机构信息
Northwest Minzu University College of Medicine, Lanzhou 730050, China.
Department of Oncology, the 940th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army, Lanzhou 730050, China.
出版信息
Zhongguo Fei Ai Za Zhi. 2025 Apr 20;28(4):319-324. doi: 10.3779/j.issn.1009-3419.2025.102.15.
Non-small cell lung cancer (NSCLC), a leading cause of cancer-related deaths worldwide, remains a significant clinical challenge despite advances in immune checkpoint inhibitors therapy, with drug resistance persisting as a major obstacle. Palmitoylation, a critical post-translational modification (PTM) primarily catalyzed by palmitoyltransferases of the zinc finger DHHC-type (ZDHHC), has recently demonstrated important implications in NSCLC. This review aims to elucidate the mechanisms and clinical potential of ZDHHC-mediated protein palmitoylation in NSCLC progression and immune escape. .
非小细胞肺癌（NSCLC）是全球癌症相关死亡的主要原因，尽管免疫检查点抑制剂疗法取得了进展，但它仍然是一个重大的临床挑战，耐药性仍然是主要障碍。棕榈酰化是一种关键的翻译后修饰（PTM），主要由锌指DHHC型（ZDHHC）棕榈酰转移酶催化，最近已证明在NSCLC中具有重要意义。本综述旨在阐明ZDHHC介导的蛋白质棕榈酰化在NSCLC进展和免疫逃逸中的机制及临床潜力。
Zotero 插件