NoviNano Inc., 5 Pasternaka Str., 79015 Lviv, Ukraine; Department of Applied Physics and Nanomaterials Science, Lviv Polytechnic National University, 12, S.Bandera Str, 79013 Lviv, Ukraine.
Institute of Physics, University of Tartu, 1 Ostwaldi str., 50411 Tartu, Estonia.
Nanomedicine. 2024 Nov;62:102785. doi: 10.1016/j.nano.2024.102785. Epub 2024 Sep 20.
Dental and orthopedic implants have become routine medical technologies for tooth replacement and bone fixation. Despite significant progress in implantology, achieving sufficient osseointegration remains a challenge, often leading to implant failure over the long term. Nanotechnology offers the potential to mimic the natural patterns of living tissues, providing a promising platform for tissue engineering and implant surface design. Among the various methods for developing nanostructures, High-Regular Laser-Induced Periodic Surface Structures (HR-LIPSS) techniques stand out for their ability to fabricate highly ordered nanostructures with excellent long-range repeatability and production efficiency. In this study, we utilized an innovative technical approach to generate traditional laser-induced superficial LIPSS nanostructures, followed by detailed surface analysis using classical microscopy and physicochemical methods. Our findings demonstrate for the first time that nanostructured LIPSS surfaces can significantly enhance cell adhesion and proliferation while providing an optimal environment for cell metabolism. Given the high reproducibility, low cost, and potential of HR-LIPSS techniques to support cell growth and differentiation, this novel technology has the potential to impact both the industrial development of new implants and clinical outcomes after implantation.
口腔和骨科植入物已成为常规的牙齿替换和骨固定医疗技术。尽管在植入物学方面取得了重大进展，但实现足够的骨整合仍然是一个挑战，这往往导致长期的植入物失败。纳米技术具有模仿天然组织模式的潜力，为组织工程和植入物表面设计提供了一个有前途的平台。在开发纳米结构的各种方法中，高规则激光诱导周期性表面结构（HR-LIPSS）技术因其能够制造具有优异的长程重复性和生产效率的高度有序纳米结构而脱颖而出。在这项研究中，我们利用一种创新的技术方法生成传统的激光诱导浅层 LIPSS 纳米结构，然后使用经典显微镜和物理化学方法进行详细的表面分析。我们的研究结果首次表明，纳米结构的 LIPSS 表面可以显著增强细胞的黏附和增殖，同时为细胞代谢提供最佳环境。鉴于 HR-LIPSS 技术具有高重复性、低成本和支持细胞生长和分化的潜力，这项新技术有可能对新植入物的工业发展和植入后的临床结果产生影响。
