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先天性心脏病手术后接受体外膜肺氧合治疗的新生儿循环蛋白质组的破坏：一项巢式病例对照研究。

Disruption of the Circulating Proteome in Neonates Receiving Extracorporeal Membrane Oxygenation Following Congenital Heart Disease Surgery: A Nested Case-Control Study.

作者信息

Thomson Lindsay M, Niemiec Sierra, Mancuso Christopher A, Khailova Ludmila, Ali Eiman, Syed Aneesa, Wolfe Kelly R, Zakrzewski Jack, Stone Matthew, Hyslop Robert, Frank Benjamin S, Davidson Jesse A

机构信息

Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO.

Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO.

出版信息

J Pediatr. 2025 Jan;276:114322. doi: 10.1016/j.jpeds.2024.114322. Epub 2024 Sep 19.

DOI:10.1016/j.jpeds.2024.114322
PMID:39306320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11645209/
Abstract

This nested case-control study identified broad dysregulation of the circulating proteome in neonates receiving postoperative extracorporeal membrane oxygenation support after congenital heart disease surgery, including differential responses in those not surviving to hospital discharge. Tissue hypoxia and mitochondrial-associated proteins may represent novel candidate biomarkers for poor extracorporeal membrane oxygenation outcomes.

摘要

这项巢式病例对照研究发现，先天性心脏病手术后接受术后体外膜肺氧合支持的新生儿循环蛋白质组存在广泛失调，包括未存活至出院者的不同反应。组织缺氧和线粒体相关蛋白可能是体外膜肺氧合不良结局的新候选生物标志物。

相似文献

1
Disruption of the Circulating Proteome in Neonates Receiving Extracorporeal Membrane Oxygenation Following Congenital Heart Disease Surgery: A Nested Case-Control Study.先天性心脏病手术后接受体外膜肺氧合治疗的新生儿循环蛋白质组的破坏：一项巢式病例对照研究。
J Pediatr. 2025 Jan;276:114322. doi: 10.1016/j.jpeds.2024.114322. Epub 2024 Sep 19.
2
Association of Extracorporeal Membrane Oxygenation Support Adequacy and Residual Lesions With Outcomes in Neonates Supported After Cardiac Surgery.体外膜肺氧合支持充分性及残余病变与心脏手术后接受支持的新生儿预后的相关性
Pediatr Crit Care Med. 2016 Nov;17(11):1045-1054. doi: 10.1097/PCC.0000000000000943.
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Residual lesions in postoperative pediatric cardiac surgery patients receiving extracorporeal membrane oxygenation support.体外膜肺氧合支持下接受心脏手术后的儿科患者的残留病变。
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Racial variations in extracorporeal membrane oxygenation use following congenital heart surgery.体外膜肺氧合在先天性心脏手术后的使用存在种族差异。
J Thorac Cardiovasc Surg. 2018 Jul;156(1):306-315. doi: 10.1016/j.jtcvs.2018.02.103. Epub 2018 Apr 6.
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Delayed extracorporeal membrane oxygenation in children after cardiac surgery: two-institution experience.心脏手术后儿童延迟体外膜肺氧合：两家机构的经验
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Extracorporeal membrane oxygenation in children after repair of congenital cardiac lesions.先天性心脏病变修复术后儿童的体外膜肺氧合
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Preoperative extracorporeal membrane oxygenation as a bridge to cardiac surgery in children with congenital heart disease.术前体外膜肺氧合作为先天性心脏病患儿心脏手术的桥梁。
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Pediatr Cardiol. 2017 Feb;38(2):314-323. doi: 10.1007/s00246-016-1515-3. Epub 2016 Nov 24.

本文引用的文献

1
The serum proteome of VA-ECMO patients changes over time and allows differentiation of survivors and non-survivors: an observational study.VA-ECMO 患者的血清蛋白质组随时间变化，并可区分存活者和非存活者：一项观察性研究。
J Transl Med. 2023 May 12;21(1):319. doi: 10.1186/s12967-023-04174-8.
2
Extensive mitochondrial proteome disturbance occurs during the early stages of acute myocardial ischemia.在急性心肌缺血的早期阶段，会发生广泛的线粒体蛋白质组紊乱。
Exp Ther Med. 2022 Jan;23(1):85. doi: 10.3892/etm.2021.11008. Epub 2021 Nov 25.
3
Regulation of Fibroblast Growth Factor 23 by Iron, EPO, and HIF.铁、促红细胞生成素和低氧诱导因子对成纤维细胞生长因子23的调节
Curr Mol Biol Rep. 2019 Mar;5(1):8-17. doi: 10.1007/s40610-019-0110-9. Epub 2019 Jan 25.
4
Transcranial Doppler Identification of Neurologic Injury during Pediatric Extracorporeal Membrane Oxygenation Therapy.经颅多普勒超声在小儿体外膜肺氧合治疗期间对神经损伤的识别
J Stroke Cerebrovasc Dis. 2017 Oct;26(10):2336-2345. doi: 10.1016/j.jstrokecerebrovasdis.2017.05.022. Epub 2017 Jun 2.
5
Factors Associated with Bleeding and Thrombosis in Children Receiving Extracorporeal Membrane Oxygenation.接受体外膜肺氧合治疗的儿童出血与血栓形成的相关因素
Am J Respir Crit Care Med. 2017 Sep 15;196(6):762-771. doi: 10.1164/rccm.201609-1945OC.
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Acute renal failure during extracorporeal support in the pediatric cardiac patient.小儿心脏病人体外支持期间的急性肾衰竭
ASAIO J. 2009 Jul-Aug;55(4):412-6. doi: 10.1097/MAT.0b013e31819ca3d0.
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Seizures as a predictor of long-term neurodevelopmental outcome in survivors of neonatal extracorporeal membrane oxygenation (ECMO).癫痫发作作为新生儿体外膜肺氧合（ECMO）幸存者长期神经发育结局的预测指标。
J Child Neurol. 2004 Dec;19(12):930-4. doi: 10.1177/08830738040190120401.