Department of Cell and Molecular Pharmacology & Experimental Therapeutics, Medical University of South Carolina, SC, United States.
Department of Cell and Molecular Pharmacology & Experimental Therapeutics, Medical University of South Carolina, SC, United States.
Adv Cancer Res. 2024;164:93-110. doi: 10.1016/bs.acr.2024.04.010. Epub 2024 May 15.
Cancer remains a complex and multifaceted disease, characterized by a myriad of molecular and cellular alterations that collectively drive tumorigenesis and progression. Hanahan and Weinberg's concept of cancer hallmarks has offered a framework for comprehending the various but related aspects of cancer biology. Initially defined as a set of six hallmarks, further investigation has added more characteristics to this list that also contribute to the malignant phenotype. Changes in cellular energetics, proliferative signaling, and resistance to cell death are three of these hallmarks that have been thoroughly investigated and described. But new discoveries in the field of cancer biology have brought attention to the importance of another aspect of the biology of cancer: the dysregulation of membrane potential.
癌症仍然是一种复杂且多方面的疾病，其特征是存在无数分子和细胞改变，这些改变共同驱动肿瘤的发生和发展。Hanahan 和 Weinberg 的癌症标志概念为理解癌症生物学的各种但相关方面提供了一个框架。最初被定义为一组六个标志，进一步的研究已经在这个列表中添加了更多的特征，这些特征也有助于恶性表型。细胞能量代谢、增殖信号和抗细胞死亡的改变是这三个标志中的三个，它们已经被深入研究和描述。但是癌症生物学领域的新发现引起了人们对癌症生物学另一个方面的重视：膜电位的失调。
