Shakir Sara, Boissinot Sylvaine, Michon Thierry, Lafarge Stéphane, Zaidi Syed S
UMR Biologie du Fruit et Pathologie, INRAE, Université de Bordeaux, 33882, Villenave d'Ornon, France.
UMR Biologie du Fruit et Pathologie, INRAE, Université de Bordeaux, 33882, Villenave d'Ornon, France.
Trends Plant Sci. 2024 Dec;29(12):1331-1341. doi: 10.1016/j.tplants.2024.09.001. Epub 2024 Sep 20.
Viruses explore the potential multifunctional capacity of the proteins encoded in their compact genome to establish infection. P4 of luteoviruses has emerged as one such multifunctional protein. Expressed from an open reading frame (ORF) nested within coat protein ORF, it displays diverse subcellular localizations and interactions, reflecting its complex role in virus infection. In this review we explore how P4, constrained by overlapping ORFs, has evolved multiple functional motifs. We analyze these motifs' conservation across different barley yellow dwarf virus (BYDV) species and related poleroviruses. We also discuss how viral proteins cooperate to facilitate movement and localization of the virus throughout infection. We provide insights into potential future research directions and suggest strategies for developing potential antiviral-resistant approaches.
病毒利用其紧凑基因组中编码的蛋白质的潜在多功能能力来建立感染。黄症病毒属的P4蛋白就是这样一种多功能蛋白。它由衣壳蛋白开放阅读框（ORF）内嵌套的一个开放阅读框表达，表现出多种亚细胞定位和相互作用，反映了其在病毒感染中的复杂作用。在这篇综述中，我们探讨了受重叠开放阅读框限制的P4蛋白是如何进化出多种功能基序的。我们分析了这些基序在不同大麦黄矮病毒（BYDV）物种和相关马铃薯卷叶病毒中的保守性。我们还讨论了病毒蛋白如何协同作用以促进病毒在整个感染过程中的移动和定位。我们深入探讨了未来潜在的研究方向，并提出了开发潜在抗病毒抗性方法的策略。
