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中耳结核的临床见解:诊断、治疗及管理结果

Clinical insights into tuberculosis otitis media: diagnosis, treatment, and management outcomes.

作者信息

Peng Zhe, Chen Zhong-Rui, Xu Hai-Yan, Wang Lin-E, Gong Shu-Sheng

机构信息

Department of Otolaryngology-Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.

Clinical Center for Hearing Loss, Capital Medical University, Beijing, 100050, China.

出版信息

Eur Arch Otorhinolaryngol. 2025 Feb;282(2):743-751. doi: 10.1007/s00405-024-08977-3. Epub 2024 Sep 22.

Abstract

OBJECTIVES

The diagnosis of tuberculosis otitis media (TBOM) remains a great challenge. This study aims to suggest potential diagnostic clues and proper management of TBOM.

METHODS

The study is a retrospective review of TBOM cases that were treated at our department, between January 2015 and June 2023. Summarizing their clinical characteristics, diagnosis, and treatment. Additionally, a literature review is conducted.

RESULTS

Eight cases of TBOM, 6 female and 2 male patients, median age was 32 years old, were included in the study. TBOM mainly presents with symptoms of otorrhea, hearing loss, and occasional early-onset facial palsy. One case had a positive Purified Protein Derivative (PPD) before the operation. Middle ear tissue was pathologically biopsied in 7 cases, with 3 cases testing positive for Acid Fast Bacillus and 6 cases testing positive for Mycobacterium tuberculosis PCR. Middle ear surgery and Anti-tubercular treatment (ATT) were completed in all cases. The median follow-up was 11 months. No cases of TB relapse were observed.

CONCLUSIONS

Proper suspicion and confirmation of TBOM is the primary clinical orientation. Middle ear surgery combination with ATT results in satisfactory outcomes. Hearing reconstruction should be performed after ATT is completed.

摘要

目的

中耳结核(TBOM)的诊断仍然是一项巨大挑战。本研究旨在提出TBOM的潜在诊断线索及恰当的治疗方法。

方法

本研究是对2015年1月至2023年6月在我科接受治疗的TBOM病例进行的回顾性分析。总结其临床特征、诊断及治疗情况。此外,还进行了文献综述。

结果

本研究纳入了8例TBOM患者,其中女性6例,男性2例,中位年龄为32岁。TBOM主要表现为耳漏、听力损失,偶尔伴有早期面瘫症状。1例患者术前结核菌素纯蛋白衍生物(PPD)试验呈阳性。7例患者进行了中耳组织病理活检,3例抗酸杆菌检测呈阳性,6例结核分枝杆菌聚合酶链反应(PCR)检测呈阳性。所有病例均完成了中耳手术及抗结核治疗(ATT)。中位随访时间为11个月。未观察到结核复发病例。

结论

对TBOM进行恰当的怀疑和确诊是主要的临床方向。中耳手术联合ATT可取得满意疗效。应在完成ATT后进行听力重建。

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