Rangel Maria Adriana, Calejo Rita, Lopes Vilma, Campos Rosa Arménia, Leite Ana Luísa
Paediatric Endocrinology and Diabetology Unit, Unidade de Saúde Local de Gaia e Espinho, Rua Conceição Fernandes, Vila Nova de Gaia, 4430, Portugal.
Pediatrics Department, Centro Hospitalar de Tamega e Sousa, Avenida do Hospital Padre Américo 210, 4564-007 Penafiel, Portugal.
Ann Endocrinol (Paris). 2025 Apr;86(2):101670. doi: 10.1016/j.ando.2024.09.004. Epub 2024 Sep 20.
This study aimed to assess the body composition of pediatric patients with type-1 diabetes (T1D) in a Portuguese pediatric endocrinology/diabetic clinic, using the InBody 570 bioimpedance system. Preschool children (<6 years) and those recently diagnosed (<6 months) were excluded.
The study included 78 patients (53% female). Median age at assessment was 14 years, with 81% pubertal children. Eighty-seven percent were using continuous subcutaneous insulin infusion (CSII), 25% with an automated closed-loop model. Median HbA1c was 7.3%. Most had an adequate body mass index (BMI) standard deviation score (62%) and 48% engaged in regular physical exercise (PE) outside of school. Median percentage body fat (PBF) was 21.5% and was abnormal in 48%, with median visceral adiposity of 4. Despite adequate BMI, 11% had excessive PBF. PBF was significantly associated with visceral fat (r=0.79; P<0.001), female gender (P<0.001) and PE performed out of school (P=0.005). PE was associated with lower PBF (P=0.005), lower visceral fat (P=0.002), and higher muscle-to-fat ratio (P=0.006).
Engaging in physical exercise out of school correlated significantly with improved body composition, characterized by reduced PBF and diminished visceral adiposity. Considering the known benefits of physical exercise for metabolic and glycemic control, this study highlights the importance of promoting regular physical exercise in T1D patients.
本研究旨在使用InBody 570生物电阻抗系统评估葡萄牙一家儿科内分泌/糖尿病诊所中1型糖尿病（T1D）患儿的身体成分。排除学龄前儿童（<6岁）和近期确诊（<6个月）的儿童。
该研究纳入了78名患者（53%为女性）。评估时的中位年龄为14岁，81%为青春期儿童。87%的患者使用持续皮下胰岛素输注（CSII），25%使用自动闭环模型。糖化血红蛋白（HbA1c）的中位数为7.3%。大多数患者的体重指数（BMI）标准差评分正常（62%），48%的患者在学校外进行定期体育锻炼（PE）。身体脂肪百分比（PBF）的中位数为21.5%，48%的患者该指标异常，内脏脂肪中位数为4。尽管BMI正常，但11%的患者PBF过高。PBF与内脏脂肪显著相关（r=0.79；P<0.001）、女性性别（P<0.001）以及校外进行的体育锻炼（P=0.005）。体育锻炼与较低的PBF（P=0.005）、较低的内脏脂肪（P=0.002）以及较高的肌肉与脂肪比例（P=0.006）相关。
校外进行体育锻炼与身体成分改善显著相关，表现为PBF降低和内脏脂肪减少。考虑到体育锻炼对代谢和血糖控制的已知益处，本研究强调了在T1D患者中促进定期体育锻炼的重要性。
