Hengyang Medical College, University of South China, Hengyang, 421001, Hunan Province, China.
Hengyang Medical College, University of South China, Hengyang, 421001, Hunan Province, China.
Exp Cell Res. 2024 Oct 1;442(2):114263. doi: 10.1016/j.yexcr.2024.114263. Epub 2024 Sep 20.
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune inflammatory disorder characterized by alterations in the balance between inflammatory and regulatory cytokines. Mesenchymal stem cells (MSCs), which are non-hematopoietic stem cells with multipotent differentiation potential, due to their immunomodulatory, tissue repair, low immunogenicity, and chemotactic properties, have garnered increasing interest in SLE treatment. Studies increasingly reveal the heterogeneous nature of MSC populations. With sources including dental pulp, adipose tissue, bone marrow, and umbilical cord, the therapeutic effects of MSCs on SLE vary depending on their origin. This review consolidates clinical research on MSCs from different sources in treating SLE and analyzes the possible causes underlying these variable outcomes. Additionally, it elucidates five potential factors impacting the outcomes of MSC therapy in SLE: the influence of the microenvironment on MSCs, the complexity and paradoxical aspects of MSC mechanisms in SLE treatment, the heterogeneity of MSCs, the in vivo differentiation potential and post-transplant survival rates of MSCs, and disparities in MSC preparation conditions.
系统性红斑狼疮（SLE）是一种慢性自身免疫性炎症性疾病，其特征是炎症和调节性细胞因子之间的平衡发生改变。间充质干细胞（MSCs）是具有多向分化潜能的非造血干细胞，由于其免疫调节、组织修复、低免疫原性和趋化特性，在 SLE 的治疗中受到越来越多的关注。研究越来越揭示 MSC 群体的异质性。MSCs 的来源包括牙髓、脂肪组织、骨髓和脐带，其对 SLE 的治疗效果因来源而异。本综述综合了不同来源的 MSC 治疗 SLE 的临床研究，并分析了这些可变结果的可能原因。此外，它还阐明了影响 SLE 中 MSC 治疗结果的五个潜在因素：微环境对 MSC 的影响、SLE 治疗中 MSC 机制的复杂性和矛盾性、MSC 的异质性、MSC 的体内分化潜能和移植后存活率，以及 MSC 制备条件的差异。
