遗传因素对系统性红斑狼疮间充质干细胞功能障碍的影响。
Genetic contribution to mesenchymal stem cell dysfunction in systemic lupus erythematosus.
机构信息
Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, China.
出版信息
Stem Cell Res Ther. 2018 May 24;9(1):149. doi: 10.1186/s13287-018-0898-x.
Abstract
Allogeneic mesenchymal stem cell (MSC) transplantation has recently become a promising therapy for patients with systemic lupus erythematosus (SLE). MSCs are a kind of multipotent stem cell than can efficiently modulate both innate and adaptive immune responses, yet those from SLE patients themselves fail to maintain the balance of immune cells, which is partly due to the abnormal genetic background. Clarifying genetic factors associated with MSC dysfunction may be helpful to delineate SLE pathogenesis and provide new therapeutic targets. In this review, the scientific evidence on the genetic contribution to MSC dysfunction in SLE is summarized.
摘要
同种异体间充质干细胞（MSC）移植最近已成为治疗系统性红斑狼疮（SLE）患者的一种有前途的疗法。间充质干细胞是一种多能干细胞，能够有效地调节先天和适应性免疫反应，但来自 SLE 患者自身的间充质干细胞未能维持免疫细胞的平衡，这在一定程度上是由于异常的遗传背景。阐明与间充质干细胞功能障碍相关的遗传因素可能有助于阐明 SLE 的发病机制，并提供新的治疗靶点。在这篇综述中，总结了有关 SLE 中 MSC 功能障碍的遗传贡献的科学证据。
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本文引用的文献
1
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Cell Transplant. 2017 Jun 9;26(6):1031-1042. doi: 10.3727/096368917X694660. Epub 2017 Jan 20.
2
Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria.
Stem Cells Int. 2016;2016:4062789. doi: 10.1155/2016/4062789. Epub 2016 Dec 7.
3
TNF-α enhances vascular cell adhesion molecule-1 expression in human bone marrow mesenchymal stem cells via the NF-κB, ERK and JNK signaling pathways.
Mol Med Rep. 2016 Jul;14(1):643-8. doi: 10.3892/mmr.2016.5314. Epub 2016 May 19.
4
Interaction between Mesenchymal Stem Cells and B-Cells.
Int J Mol Sci. 2016 May 5;17(5):650. doi: 10.3390/ijms17050650.
5
Functional Role of FcγRIIB in the Regulation of Mesenchymal Stem Cell Function.
Int J Med Sci. 2016 Feb 5;13(2):154-60. doi: 10.7150/ijms.13649. eCollection 2016.
6
Mesenchymal stem cells promote CD206 expression and phagocytic activity of macrophages through IL-6 in systemic lupus erythematosus.
Clin Immunol. 2015 Dec;161(2):209-16. doi: 10.1016/j.clim.2015.07.011. Epub 2015 Jul 22.
7
FcγRIIB Gene Polymorphisms Are Associated with Disease Risk and Clinical Manifestations of Systemic Lupus Erythematosus in Koreans.
Tohoku J Exp Med. 2015 Jul;236(3):185-91. doi: 10.1620/tjem.236.185.
8
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9
Association of TNF-α with impaired migration capacity of mesenchymal stem cells in patients with systemic lupus erythematosus.
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10
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