赤霉素（GA）：用于药物合成的多功能手性砌块。

Alabdeen Khdar Zein, Le Tam Minh, Szakonyi Zsolt

Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös utca 6, H-6720, Szeged, Hungary.

HUN-REN-SZTE Stereochemistry Research Group of the Hungarian Academy of Sciences, Eötvös utca 6, H-6720, Szeged, Hungary.

Chem Biodivers. 2025 Jan;22(1):e202401823. doi: 10.1002/cbdv.202401823. Epub 2024 Nov 4.

Gibberellic acid (GA), an ent-kaurene tetracyclic diterpene, has been considered to be a chiral pool for the chemical transformation of significant heterocyclic compounds. This chiral pool continues to influence modern synthetic chemistry as an inexpensive and versatile starting material since it is widely applied in agriculture. This review focuses on the stereoselective syntheses of bioactive agents with pharmaceutical potency prepared from Gibberellic acid.

赤霉酸（GA），一种对映-贝壳杉烯四环二萜，被认为是重要杂环化合物化学转化的手性源。由于其在农业中广泛应用，作为一种廉价且通用的起始原料，这个手性源持续影响着现代合成化学。本综述重点关注由赤霉酸制备的具有药物活性的生物活性剂的立体选择性合成。