Zhao T, Bai M, Wang R, Zhao M, Tian R R, Xing J, Lin Y M, Zhou J, Yuan L
Department of Nuclear Medicine (PET/CT) , China Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030013, China School of Forensic Medicine, Shanxi Medical University, Taiyuan 030001, China.
Department of Hematology, China Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030013, China.
Zhonghua Xue Ye Xue Za Zhi. 2024 Aug 14;45(8):776-780. doi: 10.3760/cma.j.cn121090-20240208-00059.
Follicular lymphoma (FL) is highly heterogeneous with different histopathologic grades. Its biological characteristics and clinical management are different. This study retrospectively analyzed (18)F-FDG PET-CT metabolic parameters, clinical features, and their relationship with prognosis in 161 FL patients with different histopathological grades (grade 1-2, grade 3A, grade 3B) at the Shanxi Cancer Hospital. There were 93 cases in the grade 1-2 group, 40 cases in the grade 3A group, and 28 cases in the grade 3B group. The expression of LDH, CD10, EZH2, c-Myc, and CD37 proteins was correlated with histological grade (grade 1-2, grade 3A, and grade 3B) (all values<0.05) . The SUVmax, TLG, TBR, and TLR for the three groups were different (all values<0.05) . The optimal thresholds of SUVmax, MTV, TLG, TBR, and TLR for predicting FL disease progression were 8.32, 201.31, 2 342.55, 6.56, and 3.52, respectively, and the rate of disease progression increased in patients with higher thresholds (all value<0.05) . β(2)-MG (>2.3 μg/L) , Follicular lymphoma international prognostic index-1 (FLIPI-1) score (3-5 points) , negative CD37 expression, positive c-Myc expression, and TLG (>2 342.55 g) were all independent risk factors for PFS in the FL patients (=3.609, 2.509, 0.255, 3.506, 13.531, all value<0.05) . (18)F-FDG PET-CT is a powerful complement to FL histopathological grading and the combination of the two may better predict the prognosis of FL patients.
滤泡性淋巴瘤（FL）具有高度异质性，存在不同的组织病理学分级。其生物学特性和临床管理各不相同。本研究回顾性分析了山西医科大学附属肿瘤医院161例不同组织病理学分级（1-2级、3A级、3B级）的FL患者的（18）F-FDG PET-CT代谢参数、临床特征及其与预后的关系。1-2级组93例，3A级组40例，3B级组28例。LDH、CD10、EZH2、c-Myc和CD37蛋白的表达与组织学分级（1-2级、3A级和3B级）相关（所有P值<0.05）。三组的SUVmax、TLG、TBR和TLR不同（所有P值<0.05）。预测FL疾病进展的SUVmax、MTV、TLG、TBR和TLR的最佳阈值分别为8.32、201.31、2342.55、6.56和3.52，阈值越高患者疾病进展率越高（所有P值<0.05）。β2-MG（>2.3μg/L）、滤泡性淋巴瘤国际预后指数-1（FLIPI-1）评分（3-5分）、CD37表达阴性、c-Myc表达阳性和TLG（>2342.55g）均为FL患者无进展生存期的独立危险因素（χ2=3.609、2.509、0.255、3.506、13.531，所有P值<0.05）。（18）F-FDG PET-CT是FL组织病理学分级的有力补充，两者结合可能更好地预测FL患者的预后。
