The Fourth Central Clinical College, Tianjin Medical University, Tianjin, China.
Department of Orthopedics, The Fourth Central Clinical College, Tianjin Medical University, Tianjin, China.
Osteoporos Int. 2024 Dec;35(12):2215-2223. doi: 10.1007/s00198-024-07249-4. Epub 2024 Sep 23.
This study, using Mendelian randomization, reveals a causal link between nitrogen oxides and PM2.5 exposure and reduced total-body bone mineral density, highlighting a potential risk factor for osteoporosis. The findings emphasize the importance of targeted interventions in populations exposed to higher air pollution.
With the aging of the population, the prevalence of osteoporosis is escalating. Observational studies suggest that air pollution might diminish bone mineral density (BMD), contributing to elevating the likelihood of developing osteoporosis.
Employing a two-sample Mendelian randomization (MR) analysis, our study aimed to explore the potential causal effect of air pollution on total-body BMD. We utilized extensive publicly available data from genome-wide association studies (GWAS) in this research. Inverse variance weighting was selected for the primary effect estimation, complemented by additional approaches such as the weighted median, MR-Egger, simple mode, and weighted mode. Sensitivity analyses were then conducted to evaluate heterogeneity, pleiotropy, and the presence of outliers.
In the MR analysis, our findings revealed causal associations between nitrogen oxides (β = - 0.55, 95% CI - 0.90 to - 0.21, P = 0.002) and particulate matter (PM) 2.5 (β = - 0.33, 95% CI - 0.59 to - 0.08, P = 0.010) and a reduction in total-body BMD. No significant associations were detected between PM2.5-10, PM10, nitrogen dioxide, and total-body BMD (P > 0.05). Rigorous sensitivity analyses verified the stability of these significant results.
Our study illustrates that exposure to nitrogen oxides and PM2.5 may lead to a decrease in total-body BMD, increasing the risk of osteoporosis. This evidence holds crucial implications for policymakers and healthcare providers, as it can provide targeted interventions for the prevention of osteoporosis.
本研究采用孟德尔随机化方法，揭示了氮氧化物和 PM2.5 暴露与全身骨密度降低之间存在因果关系，突显了骨质疏松症的一个潜在风险因素。这些发现强调了在暴露于较高空气污染的人群中进行有针对性干预的重要性。
随着人口老龄化，骨质疏松症的患病率正在上升。观察性研究表明，空气污染可能会降低骨密度（BMD），增加骨质疏松症的发病风险。
本研究采用两样本孟德尔随机化（MR）分析，旨在探讨空气污染对全身 BMD 的潜在因果影响。我们在这项研究中利用了来自全基因组关联研究（GWAS）的广泛公开数据。我们选择逆方差加权法进行主要效应估计，并辅以加权中位数、MR-Egger 法、简单模式和加权模式等其他方法。然后进行敏感性分析以评估异质性、多效性和异常值的存在。
在 MR 分析中，我们发现氮氧化物（β=-0.55，95%CI-0.90 至-0.21，P=0.002）和 PM2.5（β=-0.33，95%CI-0.59 至-0.08，P=0.010）与全身 BMD 降低之间存在因果关系。PM2.5-10、PM10、二氧化氮和全身 BMD 之间没有显著关联（P>0.05）。严格的敏感性分析验证了这些显著结果的稳定性。
本研究表明，氮氧化物和 PM2.5 的暴露可能导致全身 BMD 降低，增加骨质疏松症的风险。这一证据对政策制定者和医疗保健提供者具有重要意义，因为它可以为骨质疏松症的预防提供有针对性的干预措施。
