KIT/PDGFRA野生型胃肠道间质瘤的免疫特征探索及新抗原疫苗的潜在应用 - Suppr

Exploration of the immunologic characteristics of KIT/PDGFRA wild-type gastrointestinal stromal tumor and potential application of neoantigen vaccination.

作者信息

Li Yishan, Wang Qin, Li Lin, Yuan Shaohua, Chen Hui, Li Rutian, Liu Fangcen

机构信息

The Comprehensive Cancer Center of Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu 210008, China.

Clinical Cancer Institute of Nanjing University, Nanjing, Jiangsu 210008, China.

出版信息

Chin Med J (Engl). 2024 Nov 5;137(21):2627-2629. doi: 10.1097/CM9.0000000000003294. Epub 2024 Sep 23.

DOI:10.1097/CM9.0000000000003294

PMID:39307931

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11556965/

Abstract

摘要

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Exploration of the immunologic characteristics of KIT/PDGFRA wild-type gastrointestinal stromal tumor and potential application of neoantigen vaccination.KIT/PDGFRA野生型胃肠道间质瘤的免疫特征探索及新抗原疫苗的潜在应用

Chin Med J (Engl). 2024 Nov 5;137(21):2627-2629. doi: 10.1097/CM9.0000000000003294. Epub 2024 Sep 23.

Good survival outcome of metastatic SDH-deficient gastrointestinal stromal tumors harboring SDHA mutations.携带 SDHA 突变的转移性 SDH 缺陷型胃肠道间质瘤具有良好的生存结局。

Genet Med. 2015 May;17(5):391-5. doi: 10.1038/gim.2014.115. Epub 2014 Sep 4.

Intratumoral KIT mutational heterogeneity and recurrent KIT/ PDGFRA mutations in KIT/PDGFRA wild-type gastrointestinal stromal tumors.KIT/血小板衍生生长因子受体A（PDGFRA）野生型胃肠道间质瘤中的瘤内KIT突变异质性及复发性KIT/PDGFRA突变

Oncotarget. 2016 May 24;7(21):30241-9. doi: 10.18632/oncotarget.7148.

[Clinicopathological features and prognosis of gastrointestinal stromal tumors with gene "homozygous mutation": a multicenter retrospective cohort study].基因“纯合突变”胃肠道间质瘤的临床病理特征及预后：一项多中心回顾性队列研究

Zhonghua Wei Chang Wai Ke Za Zhi. 2021 Sep 25;24(9):804-813. doi: 10.3760/cma.j.cn.441530-20210720-00293.

Gastrointestinal stromal tumors - Summary of mutational status of the primary/secondary KIT/PDGFRA mutations, BRAF mutations and SDH defects.胃肠道间质瘤——原发/继发 KIT/PDGFRA 突变、BRAF 突变和 SDH 缺陷的突变状态总结。

Pathol Res Pract. 2019 Dec;215(12):152708. doi: 10.1016/j.prp.2019.152708. Epub 2019 Oct 29.

An overview on molecular biology of KIT/PDGFRA wild type (WT) gastrointestinal stromal tumours (GIST).KIT/PDGFRA 野生型（WT）胃肠道间质瘤（GIST）的分子生物学概述。

J Med Genet. 2013 Oct;50(10):653-61. doi: 10.1136/jmedgenet-2013-101695. Epub 2013 Jul 5.

Pediatric KIT wild-type and platelet-derived growth factor receptor alpha-wild-type gastrointestinal stromal tumors share KIT activation but not mechanisms of genetic progression with adult gastrointestinal stromal tumors.小儿KIT野生型和血小板衍生生长因子受体α野生型胃肠道间质瘤具有KIT激活，但在遗传进展机制方面与成人胃肠道间质瘤不同。

Cancer Res. 2007 Oct 1;67(19):9084-8. doi: 10.1158/0008-5472.CAN-07-1938.

Classification of KIT/PDGFRA wild-type gastrointestinal stromal tumors: implications for therapy.KIT/PDGFRA野生型胃肠道间质瘤的分类：对治疗的意义。

Expert Rev Anticancer Ther. 2015 Jun;15(6):623-8. doi: 10.1586/14737140.2015.1032941. Epub 2015 Apr 1.

The progressive fragmentation of the KIT/PDGFRA wild-type (WT) gastrointestinal stromal tumors (GIST).KIT/血小板衍生生长因子受体A（PDGFRA）野生型（WT）胃肠道间质瘤（GIST）的渐进性碎片化

J Transl Med. 2017 May 23;15(1):113. doi: 10.1186/s12967-017-1212-x.

Platelet-Derived Growth Factor Receptor-α Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1.血小板衍生生长因子受体-α通过稳定ETV1来调节KIT基因发生突变的胃肠道间质瘤细胞的增殖。

Gastroenterology. 2015 Aug;149(2):420-32.e16. doi: 10.1053/j.gastro.2015.04.006. Epub 2015 Apr 9.

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REGISTRI: Regorafenib in first-line of KIT/PDGFRA wild type metastatic GIST: a collaborative Spanish (GEIS), Italian (ISG) and French Sarcoma Group (FSG) phase II trial.REGISTRI：regorafenib 一线治疗 KIT/PDGFRA 野生型转移性 GIST：一项西班牙（GEIS）、意大利（ISG）和法国肉瘤组（FSG）合作的 II 期试验。

Mol Cancer. 2023 Aug 9;22(1):127. doi: 10.1186/s12943-023-01832-9.

A multicenter, dose-finding, phase 1b study of imatinib in combination with alpelisib as third-line treatment in patients with advanced gastrointestinal stromal tumor.一项多中心、剂量探索、1b 期研究，评估伊马替尼联合阿培利司作为三线治疗晚期胃肠间质瘤患者的疗效。

BMC Cancer. 2022 May 6;22(1):511. doi: 10.1186/s12885-022-09610-4.

A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer.一项个体化新抗原治疗联合抗 PD-1 治疗晚期黑色素瘤、非小细胞肺癌或膀胱癌患者的 Ib 期临床试验。

Cell. 2020 Oct 15;183(2):347-362.e24. doi: 10.1016/j.cell.2020.08.053.

Immune-infiltration based signature as a novel prognostic biomarker in gastrointestinal stromal tumour.基于免疫浸润的特征可作为胃肠道间质瘤的一种新型预后生物标志物。

EBioMedicine. 2020 Jul;57:102850. doi: 10.1016/j.ebiom.2020.102850. Epub 2020 Jun 20.

Imatinib in combination with phosphoinositol kinase inhibitor buparlisib in patients with gastrointestinal stromal tumour who failed prior therapy with imatinib and sunitinib: a Phase 1b, multicentre study.伊马替尼联合磷酸肌醇激酶抑制剂比帕利斯布治疗既往伊马替尼和舒尼替尼治疗失败的胃肠间质瘤患者：一项 1b 期、多中心研究。

Br J Cancer. 2020 Apr;122(8):1158-1165. doi: 10.1038/s41416-020-0769-y. Epub 2020 Mar 9.

Durable tumor regression in highly refractory metastatic wild-type GIST following treatment with nivolumab.纳武单抗治疗后高度难治性转移性野生型胃肠道间质瘤出现持久的肿瘤消退。

Oncoimmunology. 2020 Jan 13;9(1):1710064. doi: 10.1080/2162402X.2019.1710064. eCollection 2020.

Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumors.琥珀酸脱氢酶缺陷型胃肠道间质瘤。

Arch Pathol Lab Med. 2020 May;144(5):655-660. doi: 10.5858/arpa.2018-0370-RS. Epub 2019 Jun 6.

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial.在 Ib 期胶质母细胞瘤试验中，新型抗原疫苗可在肿瘤内产生 T 细胞应答。

Nature. 2019 Jan;565(7738):234-239. doi: 10.1038/s41586-018-0792-9. Epub 2018 Dec 19.

Role of immune microenvironment in gastrointestinal stromal tumours.免疫微环境在胃肠道间质瘤中的作用。

Histopathology. 2018 Feb;72(3):405-413. doi: 10.1111/his.13382. Epub 2017 Nov 21.

FGFR1 and NTRK3 actionable alterations in "Wild-Type" gastrointestinal stromal tumors.“野生型”胃肠道间质瘤中的FGFR1和NTRK3可靶向改变

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Exploration of the immunologic characteristics of KIT/PDGFRA wild-type gastrointestinal stromal tumor and potential application of neoantigen vaccination.

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