Kosakai H, Hiraoka K, Shimamoto I, Ichijo M
Jpn J Antibiot. 1985 May;38(5):1272-8.
Cefminox (CMNX, MT-141) was studied both fundamentally and clinically with following results: In the treatment of 3 cases of Bartholin's abscess, 2 cases of pyometra, and 1 case each of bartholinitis, inflammation of the pelvic dead space, retroperitoneal abscess and pelvic peritonitis, CMNX was administered at a dosage of 1 g. The global clinical results were rated as good in 9 cases. From these findings it is considered that CMNX is promising as an antibiotic with extremely high efficacy for infections of the field of obstetrics and gynecology. Furthermore, since in none of our cases side effects or laboratory abnormalities were observed, CMNX is considered to be a drug with high efficacy and safety. In 5 cases received 1 g of CMNX intravenously, concentrations of the drug in the serum and tissues of internal genital organs were determined. CMNX was maintained at concentrations higher than 20 micrograms/ml for the serum and 10 micrograms/g for each tissue studied. In the pelvic dead space exudate 10 to 20 micrograms/ml of the drug was still detected even at 8 hours after the administration. These results obtained by our fundamental study support the efficacy of CMNX demonstrated in the clinical part of our study.
对头孢米诺（CMNX，MT - 141）进行了基础和临床研究，结果如下：在治疗3例巴氏腺脓肿、2例子宫积脓、1例巴氏腺炎、盆腔死腔炎、腹膜后脓肿和盆腔腹膜炎时，头孢米诺的给药剂量为1g。9例患者的整体临床结果评定为良好。从这些结果可以认为，头孢米诺作为一种对妇产科感染具有极高疗效的抗生素很有前景。此外，由于在我们的病例中均未观察到副作用或实验室异常，所以头孢米诺被认为是一种高效且安全的药物。对5例静脉注射1g头孢米诺的患者，测定了血清及内生殖器官组织中的药物浓度。血清中头孢米诺浓度维持在高于20微克/毫升，所研究的每个组织中浓度维持在10微克/克。给药后8小时，在盆腔死腔渗出液中仍检测到10至20微克/毫升的该药物。我们基础研究获得的这些结果支持了在我们研究的临床部分所证实的头孢米诺的疗效。
