ZNF197-AS1/miR-425/GABARAPL1 axis: a novel regulatory mechanism in uveal melanoma.

This study investigates the role of the long noncoding RNA (lncRNA) in uveal melanoma (UM), focusing on its function within a competing endogenous RNA (ceRNA) network. Using the UM-related TCGA (The Cancer Genome Atlas) dataset, we analyzed the expression levels of and its correlation with and , an essential autophagy-related gene. Our analysis revealed that acts as a ceRNA by competitively binding to , resulting in the upregulation of . This interaction plays a crucial role in the growth and metastasis of UM. The expression of showed a strong correlation with the clinical outcomes of patients with UM. Furthermore, in vitro assays confirmed that impedes UM cell proliferation, migration, and invasion by modulating the axis. These findings suggest that ZNF197-AS1 can effectively inhibit UM progression through this ceRNA regulatory network. This study provides valuable insights into the molecular mechanisms underlying UM and highlights the potential of targeting the axis as a therapeutic strategy for UM. This study identifies the ZNF197-AS1/miR-425/GABARAPL1 axis as a novel regulatory mechanism in uveal melanoma. ZNF197-AS1 upregulates GABARAPL1 by sponging miR-425, inhibiting UM cell proliferation, migration, and invasion. This discovery highlights a potential therapeutic target, providing new insights into UM progression and patient outcomes.