细胞外自由水的增加与脑白质高信号负荷有关。
Increased extracellular free water is related to white matter hyperintensity burden.
机构信息
Department of Radiology, Lishui Hospital of Traditional Chinese Medicine affiliated with Zhejiang Chinese Medical University, Lishui, PR China.
Department of Neurology, Lishui Hospital of Traditional Chinese Medicine affiliated with Zhejiang Chinese Medical University, Lishui, PR China.
出版信息
Acta Radiol. 2024 Oct;65(10):1265-1271. doi: 10.1177/02841851241282085. Epub 2024 Sep 23.
BACKGROUND
Extracellular free water (FW) has important roles in the occurrence and development of white matter hyperintensity (WMH).
PURPOSE
To explore the correlations between FW and WMH burden.
MATERIAL AND METHODS
A prospective analysis was conducted using magnetic resonance imaging (MRI) data from 126 individuals. WMH burden was determined based on WMH volumes and Fazekas scores from deep and periventricular white matter hyperintensity (DWMH and PWMH, respectively) in fluid-attenuated inversion recovery (FLAIR) images. FW values were taken from diffusion tensor imaging (DTI).
RESULTS
Univariate analysis showed that FW values were correlated with WMH burden, including WMH volumes and DWMH and PWMH Fazekas scores (< 0.05). After multivariate analysis, FW values were correlated with WMH volumes and DWMH and PWMH Fazekas scores when adjusted for age and hypertension (< 0.05).
CONCLUSION
Using MRI, increasing extracellular FW was related to WMH burden.
背景
细胞外自由水（FW）在脑白质高信号（WMH）的发生和发展中具有重要作用。
目的
探讨 FW 与 WMH 负荷之间的相关性。
材料与方法
采用磁共振成像（MRI）数据对 126 例个体进行前瞻性分析。WMH 负荷基于液体衰减反转恢复（FLAIR）图像中深部和脑室周围脑白质高信号（DWMH 和 PWMH）的 WMH 体积和 Fazekas 评分确定。FW 值取自弥散张量成像（DTI）。
结果
单变量分析表明，FW 值与 WMH 负荷（包括 WMH 体积和 DWMH 和 PWMH 的 Fazekas 评分）呈正相关（<0.05）。经多变量分析，FW 值与 WMH 体积以及 DWMH 和 PWMH 的 Fazekas 评分呈正相关，校正年龄和高血压因素后（<0.05）。
结论
使用 MRI，细胞外 FW 的增加与 WMH 负荷有关。
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