Department of Epidemiology, Milken Institute School of Public Health at the George Washington University, Washington, DC, USA.
J Psychopharmacol. 2024 Oct;38(10):861-872. doi: 10.1177/02698811241278774. Epub 2024 Sep 23.
Clinical trials demonstrate that psychedelic-assisted therapy can improve mental health outcomes; however, few studies have recruited sexually diverse samples or reported information on sexual identity.
The purpose of this analysis was to examine the relationship between hallucinogen use and mental health outcomes with respect to sexual identity.
We conducted a cross-sectional analysis using data from the 2021 National Survey on Drug Use and Health to examine the relationship between hallucinogen use and psychological distress.
In a sample representative of 253,824,662 U.S. adults, the majority was heterosexual (92%), aged 50-64 (25%), women (51%), non-Hispanic White (62%), college educated (31%), and had an annual household income of $75,000 or higher (39%). The majority reported no lifetime hallucinogen use (82%) and no past month severe psychological distress (93%). Sexual identity modified the relationship between hallucinogen use and psychological distress. After stratifying by sexual identity and adjusting for covariates, hallucinogen use was associated with reduced odds of psychological distress in the heterosexual population (OR = 0.76, 95% CI: 0.59, 0.96) but the relationship was not significant in the sexual minority population.
We found that in a nationally representative sample, psychedelic use was associated with reduced odds of psychological distress in heterosexual individuals only. Future research should investigate why hallucinogen use was not protective in sexual minority groups given their disproportionate burden of poor mental health outcomes.
临床试验表明，迷幻剂辅助疗法可以改善心理健康状况；然而，很少有研究招募性多样化的样本或报告性身份信息。
本分析的目的是研究迷幻剂使用与心理健康结果之间与性身份相关的关系。
我们使用 2021 年全国毒品使用与健康调查的数据进行了横断面分析，以检查迷幻剂使用与心理困扰之间的关系。
在代表 253824662 名美国成年人的样本中，大多数人是异性恋（92%），年龄在 50-64 岁（25%），女性（51%），非西班牙裔白人（62%），受过大学教育（31%），家庭年收入为 75000 美元或更高（39%）。大多数人报告没有终生使用迷幻剂（82%），过去一个月没有严重的心理困扰（93%）。性身份改变了迷幻剂使用与心理困扰之间的关系。在按性身份分层并调整协变量后，在异性恋人群中，迷幻剂使用与心理困扰的几率降低相关（OR=0.76，95%CI：0.59，0.96），但在性少数人群中，这种关系并不显著。
我们发现，在一个具有全国代表性的样本中，迷幻剂使用与异性恋个体心理困扰几率降低相关。鉴于性少数群体心理健康状况不佳的负担不成比例，未来的研究应该调查为什么迷幻剂使用在性少数群体中没有保护作用。
