Singh Neha, Das Priya, Singh Deepak K, Zaidi Ariba
Department of Radiodiagnosis and Imaging, Dr. Ram Manohar Lohia Institute of Medical sciences, Lucknow, India.
Department of Neurosurgery, Dr. Ram Manohar Lohia Institute of Medical sciences, Lucknow, India.
Radiol Case Rep. 2024 Sep 10;19(12):5696-5707. doi: 10.1016/j.radcr.2024.08.040. eCollection 2024 Dec.
Neuroendocrine breast cancers (NEBCs) are a rare and distinct subtype of breast tumors, characterized by their neuroendocrine differentiation. Despite accounting for less than 1% of all breast cancers, NEBCs present unique diagnostic and therapeutic challenges due to their heterogeneous nature and variable prognosis. Accurate imaging plays a crucial role in the diagnosis, treatment planning, and follow-up of NEBCs, yet remains a complex area due to the rarity of these tumors and overlapping features with more common breast cancers. We present a series of 4 cases of primary NEBC, emphasizing the imaging features and their histopathological correlations. All patients presented with breast lump. Diagnostic Mammography followed by Ultrasound was performed in each case. All 4 cases were categorized as Breast Imaging- Reporting and Data System (BI-RADS)-4. Trucut biopsy was performed and histopathological analysis revealed the diagnosis of NEBC. Patients underwent Surgery followed by Chemotherapy, Hormonal Therapy or Radiation therapy alone or in combination with each other depending upon the histopathological characteristics.
神经内分泌性乳腺癌（NEBCs）是一种罕见且独特的乳腺肿瘤亚型，其特征为神经内分泌分化。尽管NEBCs在所有乳腺癌中占比不到1%，但由于其异质性和预后差异，在诊断和治疗方面存在独特挑战。准确的影像学检查在NEBCs的诊断、治疗规划及随访中起着关键作用，但由于这些肿瘤罕见且与更常见的乳腺癌存在重叠特征，这仍是一个复杂领域。我们展示了4例原发性NEBC病例，强调其影像学特征及其与组织病理学的相关性。所有患者均表现为乳腺肿块。每例患者均先进行了诊断性乳腺钼靶检查，随后进行了超声检查；所有4例均被归类为乳腺影像报告和数据系统（BI-RADS）-4类。进行了粗针活检且组织病理学分析确诊为NEBC。患者根据组织病理学特征接受了手术，随后单独或联合进行化疗、激素治疗或放射治疗。
