Abou Dalle Iman, Abbas Jaber, Boulos Fouad, Salem Ziad, Assi Hazem I
Department of Internal Medicine, Hematology-Oncology Division, American University of Beirut Medical Center, Beirut, Lebanon.
Department of Surgery, American University of Beirut Medical Center, Beirut, Lebanon.
J Med Case Rep. 2017 Oct 19;11(1):290. doi: 10.1186/s13256-017-1467-0.
Neuroendocrine breast cancer is a rare entity that was defined in 2003 by the World Health Organization as a separate breast cancer subtype. The diagnosis of neuroendocrine breast cancer requires the presence of neuroendocrine features in at least 50% of malignant cells, the exclusion of non-mammary primary tumors, as well as the presence of an in situ component in breast histology. The treatment and prognosis of neuroendocrine breast cancer are still not well established. Small cell carcinoma of the breast is a subtype of neuroendocrine cancer, resembling small cell carcinoma of the lung. It has a very poor prognosis and warrants treatment with platinum-based chemotherapy.
We herein report the case of a 47-year-old white woman with a left breast mass that was found to be an early-stage, high-grade small cell carcinoma of the breast. Positron emission tomography-computed tomography imaging excluded any other primary disease. Our patient underwent a left total mastectomy with sentinel lymph node biopsy and received cisplatin-based adjuvant chemotherapy. Our patient remains free of disease to date.
This case report sheds light on a rarely described disease and provides a comprehensive approach to diagnosis and management. Neuroendocrine carcinoma of the breast is a well-defined histologic subtype of breast cancer. Small cell carcinoma of the breast is a rare subtype of neuroendocrine breast cancer. Due to the rarity of this entity, prognosis has still not been well established, and treatment has not been standardized, cisplatin-based treatment has been used in this case similar to small cell carcinoma of the lung.
神经内分泌乳腺癌是一种罕见的疾病，2003年世界卫生组织将其定义为一种独立的乳腺癌亚型。神经内分泌乳腺癌的诊断需要至少50%的恶性细胞具有神经内分泌特征，排除非乳腺原发性肿瘤，并且乳腺组织学中存在原位成分。神经内分泌乳腺癌的治疗和预后仍未完全明确。乳腺小细胞癌是神经内分泌癌的一种亚型，类似于肺小细胞癌。其预后非常差，需要采用铂类化疗进行治疗。
我们在此报告一例47岁白人女性，其左乳肿块被发现为早期、高级别乳腺小细胞癌。正电子发射断层扫描-计算机断层扫描成像排除了任何其他原发性疾病。我们的患者接受了左乳全切除术及前哨淋巴结活检，并接受了以顺铂为基础的辅助化疗。我们的患者至今仍无疾病复发。
本病例报告揭示了一种罕见描述的疾病，并提供了全面的诊断和管理方法。乳腺神经内分泌癌是一种明确的乳腺癌组织学亚型。乳腺小细胞癌是神经内分泌乳腺癌的一种罕见亚型。由于该疾病罕见，其预后仍未完全明确，治疗也未标准化，本病例采用了类似于肺小细胞癌的以顺铂为基础的治疗方法。
