Linking Respiratory Challenges in KCNQ2 Encephalopathy to "Phox2b" Neurons in the Retrotrapezoid Nucleus.
作者信息
Gu Bin
机构信息
Department of Neuroscience, Ohio State University.
出版信息
Epilepsy Curr. 2024 May 16;24(4):289-291. doi: 10.1177/15357597241253680. eCollection 2024 Jul-Aug.
Abstract
摘要
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Linking Respiratory Challenges in KCNQ2 Encephalopathy to "Phox2b" Neurons in the Retrotrapezoid Nucleus.将KCNQ2脑病中的呼吸挑战与后包钦格复合体中的“Phox2b”神经元相联系。
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本文引用的文献
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Knockdown of PHOX2B in the retrotrapezoid nucleus reduces the central CO chemoreflex in rats.敲低梯形核中的 PHOX2B 可减少大鼠中枢 CO 化学感受反射。
Elife. 2024 May 10;13:RP94653. doi: 10.7554/eLife.94653.
2
Phox2b-expressing neurons contribute to breathing problems in Kcnq2 loss- and gain-of-function encephalopathy models.表达 Phox2b 的神经元有助于 Kcnq2 功能丧失和获得性功能脑病模型中的呼吸问题。
Nat Commun. 2023 Dec 5;14(1):8059. doi: 10.1038/s41467-023-43834-7.
3
KCNQ2/3 Gain-of-Function Variants and Cell Excitability: Differential Effects in CA1 versus L2/3 Pyramidal Neurons.KCNQ2/3 功能获得性变异与细胞兴奋性：CA1 区与 L2/3 锥体神经元的差异效应。
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Clinical characteristics of 80 subjects with KCNQ2-related encephalopathy: Results from a family-driven survey.80 例 KCNQ2 相关脑病患者的临床特征：一项以家庭为导向的调查结果。
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