杀真菌剂与白蛋白的相互作用：解析复杂关系——全面综述
Fungicide-albumin interactions: unraveling the complex relationship-a comprehensive review.
作者信息
Malik Nisar Ahmad, Nazir Nighat, Manzoor Mehak, Gull Faizan
机构信息
Department of Chemistry, Islamic University of Science and Technology, Awantipora, Pulwama, Jammu and Kashmir India.
出版信息
Biophys Rev. 2024 May 4;16(4):417-439. doi: 10.1007/s12551-024-01190-w. eCollection 2024 Aug.
Abstract
This review will give an insight into the interactions of serum albumins, which are proteins found in the blood, with fungicides. There are molecular interactions between several fungicides and two serum albumin proteins: human serum albumin (HSA) and bovine serum albumin (BSA). The main objective of this review is to through some light on the interactions of the fungicides with serum albumins and to highlight their toxicity level. The interactions of serum albumins with fungicides are complex and can be affected by the properties of the proteins themselves. This review provides valuable insight into the interactions between serum albumins and fungicides, which can help to know the efficacy and mechanism of fungicides and may help in designing new fungicides with low or no toxicity.
摘要
本综述将深入探讨血清白蛋白（血液中发现的蛋白质）与杀真菌剂之间的相互作用。几种杀真菌剂与两种血清白蛋白：人血清白蛋白（HSA）和牛血清白蛋白（BSA）之间存在分子相互作用。本综述的主要目的是阐明杀真菌剂与血清白蛋白的相互作用，并突出它们的毒性水平。血清白蛋白与杀真菌剂的相互作用很复杂，并且会受到蛋白质自身特性的影响。本综述为血清白蛋白与杀真菌剂之间的相互作用提供了有价值的见解，这有助于了解杀真菌剂的功效和作用机制，并且可能有助于设计低毒或无毒的新型杀真菌剂。
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