Khadka Ram Bahadur, Karki Khimdhoj, Pandey Jitendra, Gyawali Rabin, Chaudhary Gautam Prasad
Department of Laboratory Science, Crimson College of Technology, Affiliated with Pokhara University, Butwal-11, Devinagar, Rupandehi 32907, Nepal.
Department of Chemistry, University of Hawaii at Manoa, Honolulu, HI, USA.
Sci One Health. 2024 Aug 10;3:100076. doi: 10.1016/j.soh.2024.100076. eCollection 2024.
The Marburg virus (MARV), belonging to the family, poses a significant global health threat, emphasizing the urgency to develop Marburg virus-like particle (VLP) vaccines for outbreak mitigation. The virus's menacing traits accentuate the need for such vaccines, which can be addressed by VLPs that mimic its structure safely, potentially overcoming past limitations. Early Marburg vaccine endeavors and their challenges are examined in the historical perspectives section, followed by an exploration of VLPs as transformative tools, capable of eliciting immune responses without conventional risks. Noteworthy milestones and achievements in Marburg VLP vaccine development, seen through preclinical and clinical trials, indicate potential cross-protection. Ongoing challenges, encompassing durability, strain diversity, and equitable distribution, are addressed, with proposed innovations like novel adjuvant, mRNA technology, and structure-based design poised to enhance Marburg VLP vaccines. This review highlights the transformative potential of Marburg VLPs in countering the virus, showcasing global collaboration, regulatory roles, and health equity for a safer future through the harmonious interplay of science, regulation, and global efforts.
马尔堡病毒（MARV）属于丝状病毒科，对全球健康构成重大威胁，这凸显了开发马尔堡病毒样颗粒（VLP）疫苗以缓解疫情的紧迫性。该病毒的危险特性凸显了此类疫苗的必要性，而VLP可以安全地模拟其结构，有可能克服以往的局限性，从而满足这一需求。在历史视角部分，我们审视了早期马尔堡疫苗的研发工作及其面临的挑战，随后探讨了VLP作为变革性工具的作用，它能够引发免疫反应且不存在传统风险。通过临床前和临床试验可以看到，马尔堡VLP疫苗研发过程中的显著里程碑和成就表明其具有潜在的交叉保护作用。文中还讨论了当前面临的挑战，包括疫苗持久性、毒株多样性和公平分配等问题，并提出了一些创新方法，如新型佐剂、mRNA技术和基于结构的设计，有望增强马尔堡VLP疫苗的效果。本综述强调了马尔堡VLP在对抗该病毒方面的变革潜力，展示了全球合作、监管作用以及通过科学、监管和全球努力的和谐互动实现更安全未来的健康公平性。
