Zhou En, Xiao Xuping, Liu Bin, Tan Zhiqiang, Zhong JiaYu
Department of Otolaryngology Head and Neck Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China.
Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, China.
Front Mol Neurosci. 2024 Sep 6;17:1451226. doi: 10.3389/fnmol.2024.1451226. eCollection 2024.
Studies on feeling of ear fullness (FEF) related to sudden sensorineural hearing loss(SSNHL) are limited. The mechanisms of FEF are unclear. This study aimed to explore the characteristics and related brain activation of SSNHL with FEF.
A total of 269 SSNHL patients were prospectively observed and divided into two groups, with FEF and without FEF. Fifteen SSNHL patients with FEF and 20 healthy controls (HCs) were recruited and underwent 18F-SynVesT-1 static PET. Standardized uptake values ratios (SUVr) of 18F-SynVesT-1 were computed between regions of interest.
The occurrence of FEF was not related to the audiogram type or severity of hearing loss. There was a positive correlation between the degree of FEF and the degree of hearing loss. Recovery from FEF was not related to the audiogram shape, the degree of hearing loss or recovery. Fifteen SSNHL patients with FEF had relatively low 18F-SynVesT-1 uptake in the right middle frontal gyrus, right inferior frontal gyrus, right middle temporal gyrus, bilateral parietal lobe sub-gyral and left medial frontal gyrus, as compared with HCs. There was no relatively high 18F-SynVesT-1 uptake in the cerebral cortex.
The occurrence and recovery of FEF in SSNHL patients are not related to the classification, degree and recovery of hearing loss. The 18F-SynVesT-1 uptake in the cerebral cortex of patients experiencing SSNHL and FEF has shown alterations. This indicates that FEF may be related to cortical reorganization after the sudden impairment of unilateral auditory input.
关于与突发性感音神经性听力损失（SSNHL）相关的耳闷胀感（FEF）的研究有限。FEF的机制尚不清楚。本研究旨在探讨伴有FEF的SSNHL的特征及相关脑激活情况。
前瞻性观察269例SSNHL患者，分为有FEF组和无FEF组。招募15例有FEF的SSNHL患者和20例健康对照（HCs），进行18F - SynVesT - 1静态PET检查。计算感兴趣区域之间的18F - SynVesT - 1标准化摄取值比率（SUVr）。
FEF的发生与听力图类型或听力损失严重程度无关。FEF程度与听力损失程度呈正相关。FEF的恢复与听力图形状、听力损失程度或恢复情况无关。与HCs相比，15例有FEF的SSNHL患者在右侧额中回、右侧额下回、右侧颞中回、双侧顶叶脑回及左侧额内侧回的18F - SynVesT - 1摄取相对较低。大脑皮层没有相对较高的18F - SynVesT - 1摄取。
SSNHL患者FEF的发生和恢复与听力损失的分类、程度及恢复无关。发生SSNHL和FEF的患者大脑皮层的18F - SynVesT - 1摄取已显示出改变。这表明FEF可能与单侧听觉输入突然受损后的皮层重组有关。
